| Alumina nanoparticles alter rhythmic activities of local interneurons in the antennal lobe of Drosophila. | |
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MedLine Citation:
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PMID: 22264077 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract The special physical and chemical properties of nanomaterials open up new capabilities and functions. However, concerns have been raised about the risks produced by nanoparticles, their potential to cause undesirable effects, such as contamination of the environment and other adverse effects. In this study, we used Drosophila as a model organism to explore the effects of nano-alumina on the central nervous system. We focused on the rhythmic activities in the antennal lobe of Drosophila using patch clamps to record the electrophysiological activities. We found that 15 min after application of alumina nanoparticles, the average frequencies of spontaneous activities were significantly decreased compared with control groups (0.65 ± 0.13 Hz, 0.34 ± 0.07 Hz, *p < 0.05). These results indicated that nano-alumina might have adverse effects on the central nervous system in Drosophila. |
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Authors:
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Naya Huang; Ying Yan; Ye Xu; Ying Jin; Jiaoyao Lei; Xiaolu Zou; Dongzhi Ran; Heng Zhang; Shuo Luan; Huaiyu Gu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
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Title: Nanotoxicology Volume: - ISSN: 1743-5404 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233132 Medline TA: Nanotoxicology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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