Document Detail

Altitude sickness.
MedLine Citation:
PMID:  19454083     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Up to half of people who ascend to heights above 2500 m may develop acute mountain sickness, pulmonary oedema, or cerebral oedema, with the risk being greater at higher altitudes, and with faster rates of ascent. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions to prevent, and treat, acute mountain sickness? We searched: Medline, Embase, The Cochrane Library and other important databases up to January 2007 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS: We found 11 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: acetazolamide, dexamethasone, gingko biloba and slow ascent.
David Murdoch
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Publication Detail:
Type:  Journal Article     Date:  2007-06-01
Journal Detail:
Title:  Clinical evidence     Volume:  2007     ISSN:  1752-8526     ISO Abbreviation:  Clin Evid (Online)     Publication Date:  2007  
Date Detail:
Created Date:  2009-05-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101294314     Medline TA:  Clin Evid (Online)     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand.
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