Document Detail

Althesin (alphadione, CT 1341) a 'new' induction agent for anesthesia.
MedLine Citation:
PMID:  900959     Owner:  NLM     Status:  MEDLINE    
Althesin (alphadione) is a hypnotic agent introduced in the U.K. a few years ago by the firm of Glaxo. It is mixture of two steroids: alphaxalone 9 mg per ml and alphadolone 3 mg per ml, in solution in cremophore EL. After a concise review of the history of steroid anesthetics, the pharmacology of the new product is described. In a personal investigation, Althesin was used to induce anesthesia in 100 patients. The dose equivalent with thiopentone was determined first. It was found to amount to 52 microliter per kg corresponding to 3 mg per kg of thiopentone. A separate form was completed for each individual patient, to record the side effects, if any. The pulse and blood pressure were checked once a minute after the induction (for 5 minutes). In 8 patients the following parameters were recorded: plethysmogram, ECG, central venous pressure, pulse rhythm arterial pressure, stroke volume and cardiac output. Compared with thiopentone, Althesin is not significantly worse, but neither does it present any advantages where the circulatory parameters determined are concerned. In view of this and the recent publication concerning hypersensitivity reactions, we have ceased to use this hypnotic agent in our department.
W T Cornet; D T Popescu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archivum chirurgicum Neerlandicum     Volume:  29     ISSN:  0004-0657     ISO Abbreviation:  Arch Chir Neerl     Publication Date:  1977  
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8004861     Medline TA:  Arch Chir Neerl     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-47     Citation Subset:  IM    
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MeSH Terms
Alfaxalone Alfadolone Mixture / administration & dosage,  pharmacology*
Anesthesia, General*
Drug Evaluation
Drug Interactions
Etomidate / pharmacology
Hemodynamics / drug effects
Middle Aged
Muscles / drug effects
Pregnanediones / pharmacology*
Respiration / drug effects
Thiopental / pharmacology
Reg. No./Substance:
0/Pregnanediones; 33125-97-2/Etomidate; 76-75-5/Thiopental; 8067-82-1/Alfaxalone Alfadolone Mixture

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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