Document Detail

Alternatives to lung transplantation: treatment of pulmonary arterial hypertension.
MedLine Citation:
PMID:  21511098     Owner:  NLM     Status:  MEDLINE    
The development of targeted therapies for pulmonary arterial hypertension currently based on prostaglandin, nitric oxide, and endothelin pathways has resulted in major advances in the treatment of patients with pulmonary arterial hypertension. This article reviews the current evidence that supports both the use of mono- and combination therapy. The article also considers the role of atrial septostomy in the treatment of pulmonary arterial hypertension, particularly as a bridge to transplantation. Finally, the article provides a review of the role and outcomes of pulmonary thromboendartertectomy for patients with chronic thromboembolic pulmonary hypertension.
Paul A Corris
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in chest medicine     Volume:  32     ISSN:  1557-8216     ISO Abbreviation:  Clin. Chest Med.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-08-15     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  7907612     Medline TA:  Clin Chest Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-410     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Institute of Cellular Medicine, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, NE77DN, UK.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Atrial Septum / surgery
Epoprostenol / analogs & derivatives,  therapeutic use
Hypertension, Pulmonary* / drug therapy,  mortality,  surgery
Phosphodiesterase 5 Inhibitors / therapeutic use
Receptors, Endothelin / antagonists & inhibitors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Phosphodiesterase 5 Inhibitors; 0/Receptors, Endothelin; 35121-78-9/Epoprostenol

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