Document Detail


Alternatives to animal testing in the safety evaluation of products.
MedLine Citation:
PMID:  11827567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The conventional method for assessing the safety of products, ranging from pharmaceuticals to agrochemicals, biocides and industrial and household chemicals - including cosmetics - involves determining their toxicological properties by using experimental animals. The aim is to identify any possible adverse effects in humans by using these animal models. Providing safe products is undoubtedly of the utmost importance but, over the last decade or so, this aim has come into conflict with strong public opinion, especially in Europe, against animal testing. Industry, academia and the regulators have worked in partnership to find other ways of evaluating the safety of products, by non-animal testing, or at least by reducing the numbers of animals required and the severity of the tests in which they are used. There is a long way to go before products can be evaluated without any animal studies, and it may be that this laudable aim is an impossible dream. Nevertheless, considerable progress has been made by using a combination of in vitro tests and the prediction of properties based on chemical structure. The aim of this review is to describe these important and worthwhile developments in various areas of toxicological testing, with a focus on the European regulatory framework for general industrial and household chemicals.
Authors:
Derek J Knight; Damien Breheny
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alternatives to laboratory animals : ATLA     Volume:  30     ISSN:  0261-1929     ISO Abbreviation:  Altern Lab Anim     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-02-05     Completed Date:  2002-04-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8110074     Medline TA:  Altern Lab Anim     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-22     Citation Subset:  IM    
Affiliation:
Safepharm Laboratories Ltd, Derby DE1 2BT, UK.
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MeSH Terms
Descriptor/Qualifier:
Animal Testing Alternatives*
Animals
Carcinogenicity Tests
Dermatitis, Phototoxic
Eye Diseases / chemically induced
Mutagenicity Tests
Skin Diseases / chemically induced
Structure-Activity Relationship
Toxicity Tests*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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