| Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction. | |
| | |
MedLine Citation:
|
PMID: 20674506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Activated macrophages have been characterized as M1 and M2 according to their inflammatory response pattern. Here we analyzed the M2 marker expression and intracellular signal transduction in the course of cytokine-driven differentiation. We found elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and increased expression of CD206 by alveolar macrophages from patients with lung fibrosis. Stimulation of normal human AM with Th2 cytokines IL-4 and/or IL-10 in vitro revealed IL-4 as the most powerful inducer of M2-phenotype in AM and monocytes. Importantly, IL-10 enhanced IL-4-induced expression of CCL18 and IL-1RA in a synergistic fashion. IL-4/IL-10 stimulation induces a strong activation of STAT3 in AM from fibrosis patients. These results suggest an important role for M2 polarized AM in the pathogenesis of pulmonary fibrosis and indicate that both IL-4 and IL-10 account for human AM phenotype shift to M2, as seen in patients with fibrotic interstitial lung diseases. |
| | |
Authors:
|
Dmitri V Pechkovsky; Antje Prasse; Florian Kollert; Kathrin M Y Engel; Jan Dentler; Werner Luttmann; Karlheinz Friedrich; Joachim Müller-Quernheim; Gernot Zissel |
Related Documents
:
|
19815506 - Negative regulation of myd88-dependent signaling by il-10 in dendritic cells. 12696016 - Systemic inflammatory responses in african tick-bite fever. 21600726 - Prolactin plays a stimulatory role in ovarian follicular development and egg laying in ... 21041726 - Lipopolysaccharide-mediated il-10 transcriptional regulation requires sequential induct... 22367396 - Activation of pi3k/akt and erk signaling pathways antagonized sinomenine-induced lung c... 9033276 - Experimental production and modulation of human cytotoxic dermatitis in human-murine ch... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-31 |
Journal Detail:
|
Title: Clinical immunology (Orlando, Fla.) Volume: 137 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-17 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 89-101 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Pneumology, Medical Center, Albert-Ludwigs University, Freiburg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Bronchoalveolar Lavage Fluid / cytology Chemokines, CC / genetics, metabolism Cytokines / metabolism* Female Gene Expression / drug effects Humans Idiopathic Pulmonary Fibrosis / immunology, metabolism Interleukin 1 Receptor Antagonist Protein / genetics, metabolism Interleukin-10 / pharmacology Interleukin-4 / pharmacology Interleukin-8 / metabolism Lectins, C-Type / metabolism Macrophage Activation / drug effects, immunology* Macrophages, Alveolar / drug effects, immunology*, metabolism Male Mannose-Binding Lectins / metabolism Middle Aged Monocytes / drug effects, immunology, metabolism Pulmonary Fibrosis / etiology, immunology*, metabolism Receptors, Cell Surface / metabolism STAT Transcription Factors / metabolism Sarcoidosis, Pulmonary / complications, diagnosis, metabolism Scleroderma, Systemic / complications, metabolism Signal Transduction / drug effects, immunology* Tumor Necrosis Factor-alpha / metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Chemokines, CC; 0/Cytokines; 0/IL10 protein, human; 0/IL4 protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-8; 0/Lectins, C-Type; 0/Mannose-Binding Lectins; 0/Receptors, Cell Surface; 0/STAT Transcription Factors; 0/Tumor Necrosis Factor-alpha; 0/mannose receptor; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CD45RA expression on HCMV-specific effector memory CD8+ T cells is associated with the duration and ...
Next Document: Differentiation of attention-related problems in childhood absence epilepsy.