Document Detail


Alternative splicing of voltage-gated calcium channels: from molecular biology to disease.
MedLine Citation:
PMID:  19151996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent developments in the diversification of voltage-gated calcium channel function center on the rapidly emerging role of the posttranscriptional mechanism of alternative splicing. A number of diseases have been found to relate to the dysfunction of alternatively spliced exons arising from either genetic mutations or alterations in the splicing machinery. Mutations in some genes associated with congenital diseases have been detected to reside in alternatively spliced exons. As such, the severity of tissue-selective pathology of the disease will depend on the level of expression of the alternatively spliced exons in that tissue, as well as the extent in the change in channel properties. Importantly, alteration in channel properties is affected by the backbone array of the combinatorial alternatively spliced exons within the channel. In other words, the context by which mutations or alternatively spliced exons are expressed is a great influence on the alteration of channel properties and as such physiology and disease. We reviewed here recent comprehension of alternative splicing of voltage-gated calcium channels and how such structural and functional diversity of voltage-gated calcium channels will aid to clarify the pathophysiology of relevant diseases. Such understandings will further provide guidance for novel treatment.
Authors:
Ping Liao; Heng Yu Zhang; Tuck Wah Soong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-01-17
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  458     ISSN:  1432-2013     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-05     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  481-7     Citation Subset:  IM    
Affiliation:
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore.
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MeSH Terms
Descriptor/Qualifier:
Alternative Splicing / genetics*
Calcium Channels / physiology*
Genetic Predisposition to Disease / genetics*
Humans
Molecular Biology / trends*
RNA Splice Sites / genetics*
Chemical
Reg. No./Substance:
0/Calcium Channels; 0/RNA Splice Sites

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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