| Alternative splicing of exon 3b gives rise to ODF2 and Cenexin. | |
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MedLine Citation:
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PMID: 18160784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ODF2 was first identified as the major component of the sperm tail outer dense fibers. Additionally, ODF2 is a critical component of the mature centriole of the animal centrosome where it locates to the distal appendages. Moreover, generation of primary cilia strictly depends on ODF2. The mature centriole is characterized further by recruitment of Cenexin. Albeit highly similar in sequence the relationship between ODF2 and Cenexin has not been investigated. We demonstrate here that ODF2 and Cenexin are alternative splice products by identifying a novel exon 3b encoding Cenexin specific amino acids. Even though ODF2 is the main isoform in testicular tissue RT-PCR analyses revealed that isoforms are not restricted to specific tissues. |
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Authors:
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D Hüber; S Hoyer-Fender |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-14 |
Journal Detail:
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Title: Cytogenetic and genome research Volume: 119 ISSN: 1424-859X ISO Abbreviation: Cytogenet. Genome Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-27 Completed Date: 2008-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101142708 Medline TA: Cytogenet Genome Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 68-73 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 S. Karger AG, Basel. |
Affiliation:
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University of Göttingen, Johann-Friedrich-Blumenbach-Institut für Zoologie, Anthropologie und Entwicklungsbiologie, GZMB, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alternative Splicing
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genetics* Amino Acid Sequence Animals DNA, Complementary / genetics Exons / genetics* Gene Expression Regulation Heat-Shock Proteins / chemistry, genetics*, metabolism Humans Male Mice Molecular Sequence Data NIH 3T3 Cells Organ Specificity Protein Isoforms / chemistry, genetics, metabolism RNA, Messenger / genetics Sequence Alignment Testis / metabolism |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/Heat-Shock Proteins; 0/Odf2 protein, mouse; 0/Protein Isoforms; 0/RNA, Messenger |
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