Document Detail


Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy.
MedLine Citation:
PMID:  16102753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STREX alternative-exon adds to Slo channel a phosphorylation sequence that can invert protein kinase A (PKA) regulation from excitatory to inhibitory. Because pregnancy switches Slo responsiveness to PKA from inhibitory to excitatory, we hypothesized that STREX expression diminishes with pregnancy and is regulated by sex hormones. Different from total-rSlo, which is elevated around mid-pregnancy and decreases at term, STREX transcripts progressively decreased with pregnancy near 80% at term. STREX downregulation was mimicked by estrogen, and opposed by estrogen-receptor antagonist ICI 182,780 or progesterone (Pg). The regulation of STREX splicing directed by estrogen and Pg provides a mechanism for Slo's PKA-related phenotypic alteration with pregnancy.
Authors:
Ning Zhu; Mansoureh Eghbali; Gustavo Helguera; Min Song; Enrico Stefani; Ligia Toro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FEBS letters     Volume:  579     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2005-10-03     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  4856-60     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Division of Molecular Medicine, University of California Los Angeles, Los Angeles, CA 90095-7115, USA.
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MeSH Terms
Descriptor/Qualifier:
Alternative Splicing*
Animals
Estradiol / analogs & derivatives,  metabolism
Estrogen Antagonists / metabolism
Estrogens / metabolism*
Exons
Female
Gene Expression Regulation*
Gestational Age
Humans
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits
Large-Conductance Calcium-Activated Potassium Channels
Ovariectomy
Potassium Channels, Calcium-Activated* / chemistry,  genetics,  metabolism
Pregnancy
Progesterone / metabolism*
Protein Conformation
Protein Isoforms / genetics,  metabolism
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
HD046510/HD/NICHD NIH HHS; HL54970/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Estrogen Antagonists; 0/Estrogens; 0/Kcnma1 protein, rat; 0/Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; 0/Large-Conductance Calcium-Activated Potassium Channels; 0/Potassium Channels, Calcium-Activated; 0/Protein Isoforms; 22X328QOC4/fulvestrant; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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