Document Detail

Alternative pathway of complement in multiple myeloma.
MedLine Citation:
PMID:  6800254     Owner:  NLM     Status:  MEDLINE    
The alternative pathway of complement was studied in 16 newly diagnosed and 2 previously treated patients with multiple myeloma. Functional activity of this pathway was abnormal in 10 of these 18 patients (55%). These abnormalities correlated with depressed levels of alternative pathway components in 3 of 10 patients, but in the remaining 7, no etiology was demonstrated. There was an inverse correlation between activity and concentration of the monoclonal protein. This defect is an additional factor that may predispose patients with myeloma to overwhelming infection.
E H Kraut; A L Sagone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  11     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  335-45     Citation Subset:  IM    
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MeSH Terms
Complement Activation*
Complement Pathway, Alternative*
Complement System Proteins / analysis
Immunoglobulins / analysis
Multiple Myeloma / blood,  immunology*
Reg. No./Substance:
0/Immunoglobulins; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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