| Alternative normalization methods demonstrate widespread cortical hypometabolism in untreated de novo Parkinson's disease. | |
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MedLine Citation:
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PMID: 22695340 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: Previous positron emission tomography (PET) [18F]fluorodeoxyglucose ([18F]FDG) studies in Parkinson's disease (PD) demonstrated that moderate to late stage patients display widespread cortical hypometabolism, whereas early stage PD patients exhibit little or no cortical changes. However, recent studies suggested that conventional data normalization procedures may not always be valid, and demonstrated that alternative normalization strategies better allow detection of low magnitude changes. We hypothesized that these alternative normalization procedures would disclose more widespread metabolic alterations in de novo PD. METHODS: [18F]FDG PET scans of 26 untreated de novo PD patients (Hoehn & Yahr stage I-II) and 21 age-matched controls were compared using voxel-based analysis. Normalization was performed using gray matter (GM), white matter (WM) reference regions and Yakushev normalization. RESULTS: Compared to GM normalization, WM and Yakushev normalization procedures disclosed much larger cortical regions of relative hypometabolism in the PD group with extensive involvement of frontal and parieto-temporal-occipital cortices, and several subcortical structures. Furthermore, in the WM and Yakushev normalized analyses, stage II patients displayed more prominent cortical hypometabolism than did stage I patients. CONCLUSION: The use of alternative normalization procedures, other than GM, suggests that much more extensive cortical hypometabolism is present in untreated de novo PD patients than hitherto reported. The finding may have implications for our understanding of the basic pathophysiology of early-stage PD. |
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Authors:
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V Berti; C Polito; P Borghammer; S Ramat; L Mosconi; E Vanzi; M T De Cristofaro; M De Leon; S Sorbi; A Pupi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology Volume: 56 ISSN: 1824-4785 ISO Abbreviation: Q J Nucl Med Mol Imaging Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213861 Medline TA: Q J Nucl Med Mol Imaging Country: Italy |
Other Details:
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Languages: eng Pagination: 299-308 Citation Subset: IM |
Affiliation:
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Department of Clinical Pathophysiology, Nuclear Medicine Division, University of Florence, Florence, Italy - valentina.berti@unifi.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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