Document Detail


Alternative normalization methods demonstrate widespread cortical hypometabolism in untreated de novo Parkinson's disease.
MedLine Citation:
PMID:  22695340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Previous positron emission tomography (PET) [18F]fluorodeoxyglucose ([18F]FDG) studies in Parkinson's disease (PD) demonstrated that moderate to late stage patients display widespread cortical hypometabolism, whereas early stage PD patients exhibit little or no cortical changes. However, recent studies suggested that conventional data normalization procedures may not always be valid, and demonstrated that alternative normalization strategies better allow detection of low magnitude changes. We hypothesized that these alternative normalization procedures would disclose more widespread metabolic alterations in de novo PD.
METHODS: [18F]FDG PET scans of 26 untreated de novo PD patients (Hoehn & Yahr stage I-II) and 21 age-matched controls were compared using voxel-based analysis. Normalization was performed using gray matter (GM), white matter (WM) reference regions and Yakushev normalization.
RESULTS: Compared to GM normalization, WM and Yakushev normalization procedures disclosed much larger cortical regions of relative hypometabolism in the PD group with extensive involvement of frontal and parieto-temporal-occipital cortices, and several subcortical structures. Furthermore, in the WM and Yakushev normalized analyses, stage II patients displayed more prominent cortical hypometabolism than did stage I patients.
CONCLUSION: The use of alternative normalization procedures, other than GM, suggests that much more extensive cortical hypometabolism is present in untreated de novo PD patients than hitherto reported. The finding may have implications for our understanding of the basic pathophysiology of early-stage PD.
Authors:
V Berti; C Polito; P Borghammer; S Ramat; L Mosconi; E Vanzi; M T De Cristofaro; M De Leon; S Sorbi; A Pupi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology     Volume:  56     ISSN:  1824-4785     ISO Abbreviation:  Q J Nucl Med Mol Imaging     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-14     Completed Date:  2013-05-30     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  101213861     Medline TA:  Q J Nucl Med Mol Imaging     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  299-308     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Cerebral Cortex / metabolism*,  radionuclide imaging*
Female
Fluorodeoxyglucose F18 / diagnostic use
Glucose / metabolism
Humans
Image Processing, Computer-Assisted / methods*
Male
Middle Aged
Parkinson Disease / metabolism*,  radionuclide imaging*
Positron-Emission Tomography / methods*
Grant Support
ID/Acronym/Agency:
AG032554/AG/NIA NIH HHS; AG13616/AG/NIA NIH HHS; M01 RR000096/RR/NCRR NIH HHS; M01-RR0096/RR/NCRR NIH HHS; P30 AG008051/AG/NIA NIH HHS; R01 AG013616/AG/NIA NIH HHS; R01 AG035137/AG/NIA NIH HHS; R21 AG032554/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0Z5B2CJX4D/Fluorodeoxyglucose F18; IY9XDZ35W2/Glucose
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