| Alternative method of oral dosing for rats. | |
| | |
MedLine Citation:
|
PMID: 20587166 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Oral administration of drugs to laboratory rodents typically is achieved by using the gavage technique. Although highly effective, this method occasionally can cause esophageal injury as well as restraint-associated distress, particularly with repeated use. The aim of this study was to assess an alternative oral dosing method that could reduce the distress and morbidity associated with standard gavage techniques. The palatability and pharmacokinetic profile of 2 medicines approved for the treatment of Alzheimer disease, donepezil and galantamine, were investigated in male Lister hooded rats by using a syringe-feeding method and compared with results from traditional gavage administration. In addition, the stimulant nicotine was tested by using the syringe-feeding method in a separate series of experiments. Animals reliably learned to drink voluntarily from the syringe, and latency to drink decreased rapidly. The addition of donepezil, galantamine, or nicotine to sucrose had no apparent effect on the palatability of the solution, although nicotine produced aversive effects that inhibited subsequent voluntary intake. Oral bioavailability was improved by using syringe feeding with donepezil but not galantamine. Both drugs improved cognitive performance in the novel object recognition test, with similar behavioral profiles between the 2 methods of administration. Our results suggest that the syringe-feeding technique is an effective alternative oral dosing method in rats. |
| | |
Authors:
|
Zeenat Atcha; Claire Rourke; Aveline Hp Neo; Catherine Wh Goh; Jean Sk Lim; Chiu-Cheong Aw; Edward R Browne; Darrel J Pemberton |
Related Documents
:
|
11403996 - Male-female differences in rat hypothalamic-pituitary-adrenal axis responses to nicotin... 12479946 - Lobeline attenuates locomotor stimulation induced by repeated nicotine administration i... 7193016 - Antifibrillatory, cardiovascular and toxic effects of sparteine, butylsparteine and pen... 16472156 - Reduction of abeta levels in the sprague dawley rat after oral administration of the fu... 3746466 - Cumulative excess urinary excretion of folate in rats after repeated ethanol treatment. 23054086 - Sustained analgesia achieved through esterase-activated morphine prodrugs complexed wit... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American Association for Laboratory Animal Science : JAALAS Volume: 49 ISSN: 1559-6109 ISO Abbreviation: J. Am. Assoc. Lab. Anim. Sci. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-06-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101269489 Medline TA: J Am Assoc Lab Anim Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 335-43 Citation Subset: IM |
Affiliation:
|
Centre for Cognition and Neurodegeneration, GlaxoSmithKline R&D China, Singapore. zeenatatcha@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A spoonful of sugar helps the medicine go down: a novel technique to improve oral gavage in mice.
Next Document: Effective and safe anesthesia for Yorkshire and Yucatan swine with and without cardiovascular injury...