Document Detail


Alternative in vitro assays in nanomaterial toxicology.
MedLine Citation:
PMID:  21766468     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Nanomaterials are acclaimed for their novel properties, for which broad new uses are being discovered with increasing frequency. It is obvious that, as the properties change, unwanted properties (toxicity) are to be expected as well. Current toxicology, however, is already overwhelmed with the challenge of addressing new chemicals, not to mention the enormous number of old chemicals never properly assessed. Limitations of traditional approaches range from animal welfare issues, which were a strong driving force for alternative approaches (the 3Rs concept) over the last two decades, to aspects of throughput and accuracy of the predicted toxicities. The latter has prompted discussion about a revolutionary change in chemical safety assessment, now known as Toxicology for the 21st Century (Tox-21c). The multitude of possible formulations of nanomaterials to be assessed for novel toxic properties makes these alternative approaches especially attractive, given the well recognized limitations of traditional animal-based approaches-limitations that might be even more pronounced for nanomaterials, which have notably altered biokinetics. WIREs Nanomed Nanobiotechnol 2011 DOI: 10.1002/wnan.153 For further resources related to this article, please visit the WIREs website.
Authors:
Thomas Hartung; Enrico Sabbioni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-15
Journal Detail:
Title:  Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology     Volume:  -     ISSN:  1939-0041     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101508311     Medline TA:  Wiley Interdiscip Rev Nanomed Nanobiotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Inc.
Affiliation:
Department of Environmental Health Sciences, Center for Alternatives to Animal Testing (CAAT), Doerenkamp-Zbinden Chair for Evidence-based Toxicology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Pharmacology and Toxicology, University of Konstanz, Konstanz, Germany. THartung@jhsph.edu.
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