Document Detail

Alternative approaches in the management of poor response in controlled ovarian hyperstimulation (COH).
MedLine Citation:
PMID:  14644816     Owner:  NLM     Status:  MEDLINE    
Improving pregnancy rates in patients with many failed attempts remains a challenge during IVF-ET or ICSI-ET programs. The availability of good-quality oocytes is a prerequisite for good results in such programs. The use of a personalized protocol for controlled ovarian hyperstimulation (COH) that gives the best possible results for the specific patient is a main factor for the success in IVF or ICSI. The response of many patients to the ovarian stimulation used is very poor, giving fewer oocytes than expected, resulting in much lower, if any, pregnancy rates. The definition of a poor responder is not clear and differs among researchers. A variety of strategies have been used to improve response in these patients, regardless of the definition used. These include various ovulation induction protocols that we believe might assist these patients achieve a pregnancy. The difficulty is greater due to the fact that poor responders are not a homogeneous group and each patient may have a different cause. More studies with large numbers of patients are needed in order to find those protocols that could provide these couples with an acceptable pregnancy rate.
Dimitris Loutradis; Peter Drakakis; Spyros Milingos; Konstantine Stefanidis; Stylianos Michalas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  997     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-01-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
1st Dept OB/GYN, Athens University Medical School, Alexandria Maternity Hospital, Athens, Greece.
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MeSH Terms
Embryo Transfer
Fertility Agents, Female / adverse effects,  therapeutic use*
Fertilization in Vitro / adverse effects,  methods
Follicle Stimulating Hormone / therapeutic use
Human Growth Hormone / therapeutic use
Infertility, Female / therapy
Middle Aged
Ovarian Hyperstimulation Syndrome / prevention & control*
Ovulation Induction / adverse effects,  methods*
Pregnancy Rate / trends*
Risk Assessment
Sperm Injections, Intracytoplasmic / adverse effects,  methods
Reg. No./Substance:
0/Fertility Agents, Female; 12629-01-5/Human Growth Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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