| Alternative adaptive immunity in jawless vertebrates. | |
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MedLine Citation:
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PMID: 20660361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Jawless vertebrates use variable lymphocyte receptors (VLRs) that are generated by RAG-independent combinatorial assembly of leucine-rich repeat cassettes for Ag recognition, instead of the Ig-based Ag receptors used by jawed vertebrates. The VLR genes encode for crescent-shaped proteins that use variable beta-strands and a C-terminal loop to bind to Ags rather than the six CDR loops used by BCRs and TCRs. VLR mAbs have been isolated recently, which enabled the structure of VLR-Ag complexes to be defined. The jawless vertebrate adaptive immune system has many similarities to the Ig-based system of jawed vertebrates, including the compartmentalized development of B-like and T-like lymphocyte lineages that proliferate and differentiate into VLR-secreting plasmacytes and proinflammatory cytokine-producing cells in response to Ags. The definition of common features of the VLR-based and Ig-based systems offers fresh insight into the evolution of adaptive immunity. |
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Authors:
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Brantley R Herrin; Max D Cooper |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-09-08 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1367-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. brantley.herrin@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity*
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genetics Animals Evolution, Molecular* Hagfishes / genetics, immunology*, metabolism Immunoglobulin Variable Region / genetics, immunology, metabolism Jaw* / anatomy & histology Petromyzon / genetics, immunology*, metabolism Receptors, Antigen / genetics, immunology, metabolism Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid |
| Grant Support | |
ID/Acronym/Agency:
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5R01AI072435-05/AI/NIAID NIH HHS; R01 AI072435-06/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin Variable Region; 0/Receptors, Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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