| Alternations of phospholipid profile in placenta of streptozotocin-induced diabetic rat. | |
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MedLine Citation:
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PMID: 22103456 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Phospholipids have important roles in many biological processes, but their role in fetal malformation in pregnancy in diabetes is unclear. Metabolic fingerprinting of placental phospholipids in pregnant streptozotocin-induced type 1 diabetic rats was performed using Fourier transform-ion cyclotron resonance mass spectrometry. Some of the fetuses from the pregnant diabetic rats exhibited ventricular septal defects. Alterations of phospholipid compositions in the diabetic rat placenta were detected. We suggest that these changes in phospholipids in the diabetic placenta might be involved in development of fetal malformation in a type 1 diabetic pregnancy. |
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Authors:
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Mina Hasegawa; Katsuhiro Tanaka; Masayuki Komori; Shigeo Takenaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Congenital anomalies Volume: 51 ISSN: 1741-4520 ISO Abbreviation: Congenit Anom (Kyoto) Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306292 Medline TA: Congenit Anom (Kyoto) Country: Japan |
Other Details:
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Languages: eng Pagination: 174-6 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Congenital Anomalies © 2011 Japanese Teratology Society. |
Affiliation:
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Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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