Document Detail

Alternations in free radical erythrocyte-defense mechanisms in streptozotocin induced diabetic rats - effect of antioxidant treatment.
MedLine Citation:
PMID:  10334467     Owner:  NLM     Status:  MEDLINE    
The activities of superoxide dismutase, glutathione peroxidase and the contents of glutathione, malondialdehyde were examined in erythrocytes of streptozotocin induced diabetic rats. The above mentioned antioxidant systems of erythrocyte were determined after treatment of diabetic rats with superoxide dismutase, trolox, catalase and allopurinol. In erythrocytes of streptozotocin induced diabetic rats the activities of superoxide dismutase, glutathione peroxidase as well as the levels of reduced glutathione were lower whereas the contents of oxidized glutathione and malondialdehyde were higher than in controls. Superoxide dismutase and trolox treatment of diabetic rats resulted in an increase of erythrocyte glutathione peroxidase activities and in reduced glutathione levels. However the levels of oxidized glutathione decreased after treatment of diabetic rats with superoxide dismutase and trolox. Catalase and allopurinol administration did not have any influence on the activities of the investigated enzymes nor on the levels of glutathione in diabetic rats. The antioxidants under study did not cause any changes in the increased level of malondialdehyde in erythrocytes.
J Batko; H Witmanowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  51     ISSN:  0940-2993     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  255-6     Citation Subset:  IM    
Department of Physiological Chemistry, University of Medical Sciences, Poznan, Poland.
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MeSH Terms
Allopurinol / pharmacology
Antioxidants / metabolism*,  pharmacology
Catalase / pharmacology
Chromans / pharmacology
Diabetes Mellitus, Experimental / blood*
Erythrocytes / drug effects,  enzymology,  metabolism*
Free Radical Scavengers / blood*,  pharmacology
Glutathione / blood,  drug effects
Glutathione Disulfide / blood,  drug effects
Glutathione Peroxidase / blood,  drug effects
Malondialdehyde / blood
Rats, Wistar
Superoxide Dismutase / blood,  pharmacology
Reg. No./Substance:
0/Antioxidants; 0/Chromans; 0/Free Radical Scavengers; 27025-41-8/Glutathione Disulfide; 315-30-0/Allopurinol; 542-78-9/Malondialdehyde; 56305-04-5/6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; 70-18-8/Glutathione; EC; EC Peroxidase; EC Dismutase

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