Document Detail

Alternating hemiplegia of childhood: studies of regional cerebral blood flow using 99mTc-hexamethylpropylene amine oxime single-photon emission computed tomography.
MedLine Citation:
PMID:  8494333     Owner:  NLM     Status:  MEDLINE    
Alternating hemiplegia of childhood is a rare disorder of unknown cause associated with progressive neurological deterioration. We report the results of regional cerebral blood flow studies using 99mTc-hexamethylpropylene amine oxime single-photon emission computed tomography in 3 patients. These studies were performed during the hemiplegic attacks (n = 6) and during the symptom-free periods (n = 2). Six single-photon emission computed tomographic studies performed during hemiplegic attacks consistently showed relative hyperperfusion of the contralateral cerebral hemisphere. Two single-photon emission computed tomographic studies performed during the asymptomatic phase showed normal and symmetrical cerebral perfusion. This is the first definite demonstration of unilateral increase of cerebral blood flow in alternating hemiplegia. These findings support the possibility of a relationship between the cause of alternating hemiplegia and migraine.
A Aminian; A Strashun; A Rose
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  33     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-06-16     Completed Date:  1993-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
Department of Neurology, SUNY-Health Science Center, Brooklyn 11203.
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MeSH Terms
Brain / radionuclide imaging*
Cerebrovascular Circulation*
Child, Preschool
Hemiplegia / physiopathology*,  radionuclide imaging*
Organotechnetium Compounds / diagnostic use*
Oximes / diagnostic use*
Technetium Tc 99m Exametazime
Tomography, Emission-Computed*
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime

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