Document Detail

Alternate view on thermal stability of the DNA duplex.
MedLine Citation:
PMID:  7548049     Owner:  NLM     Status:  MEDLINE    
A concept, based on the changes in internal pressure of water due to addition of salts, has been used to interpret the thermal stability of the DNA duplexes. Dependence of thermal stability of duplexes on the salt concentrations has also been described in terms of variations in the internal pressure of water observed in presence of ionic components. The thermal stabilities at high external pressures (up to 200 MPa) compared to those at atmospheric pressure are linearly related to the corresponding variations in internal pressures at several salt concentrations.
A Kumar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry     Volume:  34     ISSN:  0006-2960     ISO Abbreviation:  Biochemistry     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12921-5     Citation Subset:  IM    
Physical Chemistry Division, National Chemical Laboratory, Pune, India.
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MeSH Terms
Base Composition
DNA / chemistry*
Hot Temperature
Nucleic Acid Denaturation
Salts / chemistry
Reg. No./Substance:
0/Salts; 9007-49-2/DNA

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