Document Detail

Alternate mucoid and hyalinized stroma in clear cell carcinoma of the ovary: manifestation of serial stromal remodeling.
MedLine Citation:
PMID:  20305617     Owner:  NLM     Status:  MEDLINE    
The stroma in ovarian clear cell carcinoma often shows alternate mucoid and hyalinized change. The hyalinized stroma is recognized to be an aberrant deposition of basement membrane material produced by tumor cells. The mucoid stroma, however, has drawn far less attention, and its significance remains unclear. We examined 60 ovarian clear cell carcinomas for the distribution and nature of the mucoid stroma. For comparison, 125 other surface epithelial ovarian tumors were examined. Twenty-nine of 60 (48%) clear cell carcinomas showed a mucoid stroma, either focally (21 cases) or diffusely (8 cases). The mucoid stroma in clear cell carcinomas was distinct from that in other surface epithelial tumors as follows: it showed a compact spherule-like appearance, commonly occupying the cores of small papillae. It also exhibited a cribriform pattern, resembling that of adenoid cystic carcinoma. It was rarely associated with stromal cells, despite the presence of abundant glycosaminoglycan including hyaluronan. Alternatively, it was strongly associated with hyalinized stroma. Among 40 clear cell carcinomas that had at least one type of stroma, 26 (65%) had both, either concomitantly or separately. The mucoid stroma tended to attenuate if the hyalinized stroma developed. In vitro, a clear cell carcinoma cell line, HAC-2, formed a spherule-like structure containing hyaluronan in the center, and a significant amount of hyaluronan was detected by latex agglutination immunoturbidimetry, indicating that HAC-2 itself has the potential to produce hyaluronan. All of these facts indicate that the spherule-like mucoid stroma and hyalinized stroma represent different phases of the stromal remodeling process, which is promoted by the deposition of different extracellular matrices produced by clear cell carcinoma cells. The spherule-like mucoid stroma and hyalinized stroma are considered complementary diagnostic signatures of ovarian clear cell carcinoma.
Noriko Kato; Junko Takeda; Masayuki Fukase; Teiichi Motoyama
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-03-19
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  23     ISSN:  1530-0285     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  881-8     Citation Subset:  IM    
Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan.
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MeSH Terms
Adenocarcinoma, Mucinous / metabolism,  pathology
Carcinoma / metabolism*,  pathology
Carcinoma, Endometrioid / metabolism,  pathology
Cell Line, Tumor
Extracellular Matrix / metabolism*
Hyaluronic Acid / metabolism*
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Mucins / metabolism*
Neoplasm Staging
Ovarian Neoplasms / metabolism*,  pathology
Stromal Cells / metabolism*,  pathology
Reg. No./Substance:
0/Mucins; 9004-61-9/Hyaluronic Acid

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