Document Detail


Alternate, adjacent 2 and 3:1 meiotic segregation products from a balanced t(13;18) (q12;q11) carrier.
MedLine Citation:
PMID:  8261649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a case in which alternate, adjacent 2 and 3:1 meiotic segregations have occurred in the pregnancies of a female carrier of a balanced reciprocal translocation -46,XX,t(13;18) (q12;q11). Products of five conceptions effectively showed trisomy 18q, trisomy 18p or monosomy 18p. This is one of the rare rearrangements which can give rise to a variety of segregation modes including adjacent 2.
Authors:
C Cotton; M Cummins; A Smith
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical genetics     Volume:  44     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-27     Completed Date:  1994-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  193-5     Citation Subset:  IM    
Affiliation:
Department of Genetics, Children's Hospital, Camperdown, NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 13*
Chromosomes, Human, Pair 18*
Female
Heterozygote
Humans
Infant, Newborn
Karyotyping
Male
Meiosis
Monosomy*
Pedigree
Pregnancy
Translocation, Genetic*
Trisomy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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