| Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults. | |
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MedLine Citation:
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PMID: 20042191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Information is scarce regarding the effect of dietary protein type, with specific focus on the lysine-to-arginine (Lys:Arg) ratio, on cardiovascular risk factors and vascular reactivity in humans. OBJECTIVE: Determine the effect of dietary Lys:Arg ratio on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults. DESIGN: Randomized cross-over design of two 35-day diet phases; thirty adults (21 females and 9 males, >or=50 years, LDL cholesterol>or=120 mg/dL). Diets had 20% energy (E) protein, 30%E fat, 50%E carbohydrate and were designed to have low (0.7) or high (1.4) Lys:Arg ratio. Measures included fasting and postprandial lipid, lipoprotein, apolipoprotein concentrations; fasting high sensitivity C-reactive protein (hsCRP), small dense LDL (sdLDL) cholesterol, remnant lipoprotein cholesterol (RemLC), glycated albumin, adiponectin and immunoreactive insulin concentrations, endogenous cholesteryl ester transfer protein (CETP) and lecithin:cholesterol acyl transferase (LCAT) activities; cholesterol fractional synthesis rate (FSR); and flow mediated dilation (FMD) and peripheral artery tonometry (PAT). RESULTS: No differences were observed in fasting and/or postprandial total, LDL, HDL and sdLDL cholesterol, RemLC, Lp(a) or apo B concentrations, LCAT and CETP activities, FSR, glycated albumin, immunoreactive insulin, FMD or PAT. The low, relative to the high, Lys:Arg ratio diet resulted in lower postprandial VLDL cholesterol (-24%, P=0.001) and triglycerides (-23%, P=0.001), and small but significant differences in fasting (-3%, P=0.003) and postprandial (-3%, P=0.018) apo AI, and fasting adiponectin concentrations (+7%, P=0.035). Fasting and postprandial hsCRP concentrations were 23% lower after the low Lys:Arg ratio diet (P=0.020 for both). CONCLUSIONS: Diets differing in Lys:Arg ratios had no or small effects on cardiovascular risk factors and vascular reactivity. |
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Authors:
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Sonia Vega-López; Nirupa R Matthan; Lynne M Ausman; Scott V Harding; Todd C Rideout; Masumi Ai; Seiko Otokozawa; Alicia Freed; Jeffrey T Kuvin; Peter J Jones; Ernst J Schaefer; Alice H Lichtenstein |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-12-05 |
Journal Detail:
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Title: Atherosclerosis Volume: 210 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-12-06 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 555-62 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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metabolism Aged Arginine / metabolism* Blood Vessels / metabolism Cardiovascular Diseases / prevention & control* Cholesterol / metabolism Cross-Over Studies Diet* Female Humans Hypercholesterolemia / diet therapy* Lysine / metabolism* Male Middle Aged Phosphatidylcholine-Sterol O-Acyltransferase / metabolism Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL 58008/HL/NHLBI NIH HHS; R01 HL058008-02/HL/NHLBI NIH HHS; R01 HL058008-03/HL/NHLBI NIH HHS; R01 HL058008-04/HL/NHLBI NIH HHS; R01 HL058008-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 56-87-1/Lysine; 57-88-5/Cholesterol; 74-79-3/Arginine; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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