| Altered waveform of plasma nocturnal melatonin secretion in premenstrual depression. | |
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MedLine Citation:
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PMID: 2244799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nocturnal secretion of plasma melatonin was determined under dim to dark conditions in eight patients with prospectively confirmed premenstrual syndrome and in eight age- and menstrual cycle phase-matched normal control subjects. Plasma samples for melatonin were collected every 30 minutes from 6 PM to 9 AM during the early follicular, late follicular, midluteal and late luteal phases of the menstrual cycle. Compared with normal controls, patients with premenstrual syndrome had an earlier (phase-advanced) offset of melatonin secretion, which contributed to a shorter secretion duration and a decreased area under the curve. No statistically significant differences were found between women with premenstrual syndrome and normal controls for melatonin onset or peak concentration, or for estradiol or progesterone levels. The data demonstrate that women with premenstrual syndrome have chronobiological abnormalities of melatonin secretion. The fact that these patients respond to treatments that affect circadian physiology, such as sleep deprivation and phototherapy, suggests that circadian abnormalities may contribute to the pathogenesis of premenstrual syndrome. |
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Authors:
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B L Parry; S L Berga; D F Kripke; M R Klauber; G A Laughlin; S S Yen; J C Gillin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of general psychiatry Volume: 47 ISSN: 0003-990X ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-01-03 Completed Date: 1991-01-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1139-46 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of California, San Diego, La Jolla 92093. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Circadian Rhythm* Estradiol / blood Female Humans Melatonin / blood*, secretion Menstrual Cycle / physiology* Personality Inventory Phototherapy Premenstrual Syndrome / blood, diagnosis*, etiology Progesterone / blood Psychiatric Status Rating Scales Sleep Deprivation |
| Grant Support | |
ID/Acronym/Agency:
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M01RR00827/RR/NCRR NIH HHS; MH30914/MH/NIMH NIH HHS; MH42831/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 57-83-0/Progesterone; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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