| Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy. | |
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MedLine Citation:
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PMID: 20503366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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EphrinB2 ligands and EphB4 receptors are expressed on endothelial cells (EC) of arteries and veins, respectively, and are essential for vascular development. To understand how these molecules regulate retinal neovascularization (NV), we evaluated their expression in a model of oxygen-induced retinopathy (OIR). EphrinB2 and EphB4 were expressed on arterial and venous trunks, respectively, and on a subset of deep capillary vessels. EphB4 expression was reduced following hyperoxia, while ephrinB2 expression remained unaltered. In addition, a subset of EphB4-positive veins regressed in a caspase-3-dependent manner during hyperoxia. Arteriovenous malformations were also observed with loss of arterial-venous boundaries. Finally, both ephrinB2 and EphB4 were expressed on a subset of neovascular tufts following hyperoxia. These data confirm the contribution of ECs from both venous and arterial origins to the development of retinal NV. |
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Authors:
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Michael H Davies; Andrew J Stempel; Kristin E Hubert; Michael R Powers |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 239 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-09-30 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 1695-707 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / metabolism Blood Vessels / metabolism* Caspase 3 / metabolism Endothelial Cells / metabolism Ephrin-B2 / metabolism* Hyperoxia / metabolism Mice Mice, Inbred C57BL Neovascularization, Pathologic / metabolism Oxygen / metabolism* Receptor, EphB4 / metabolism Retinal Neovascularization / metabolism Veins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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EY011548/EY/NEI NIH HHS; R01 EY011548-09/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ephrin-B2; 7782-44-7/Oxygen; EC 2.7.10.1/Receptor, EphB4; EC 3.4.22.-/Caspase 3 |
| Comments/Corrections | |
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