Document Detail

Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy.
MedLine Citation:
PMID:  20503366     Owner:  NLM     Status:  MEDLINE    
EphrinB2 ligands and EphB4 receptors are expressed on endothelial cells (EC) of arteries and veins, respectively, and are essential for vascular development. To understand how these molecules regulate retinal neovascularization (NV), we evaluated their expression in a model of oxygen-induced retinopathy (OIR). EphrinB2 and EphB4 were expressed on arterial and venous trunks, respectively, and on a subset of deep capillary vessels. EphB4 expression was reduced following hyperoxia, while ephrinB2 expression remained unaltered. In addition, a subset of EphB4-positive veins regressed in a caspase-3-dependent manner during hyperoxia. Arteriovenous malformations were also observed with loss of arterial-venous boundaries. Finally, both ephrinB2 and EphB4 were expressed on a subset of neovascular tufts following hyperoxia. These data confirm the contribution of ECs from both venous and arterial origins to the development of retinal NV.
Michael H Davies; Andrew J Stempel; Kristin E Hubert; Michael R Powers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-30     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1695-707     Citation Subset:  IM    
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MeSH Terms
Arteries / metabolism
Blood Vessels / metabolism*
Caspase 3 / metabolism
Endothelial Cells / metabolism
Ephrin-B2 / metabolism*
Hyperoxia / metabolism
Mice, Inbred C57BL
Neovascularization, Pathologic / metabolism
Oxygen / metabolism*
Receptor, EphB4 / metabolism
Retinal Neovascularization / metabolism
Veins / metabolism
Grant Support
EY011548/EY/NEI NIH HHS; R01 EY011548/EY/NEI NIH HHS; R01 EY011548-09/EY/NEI NIH HHS
Reg. No./Substance:
0/Ephrin-B2; EC, EphB4; EC 3.4.22.-/Caspase 3; S88TT14065/Oxygen

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