| Altered tryptophan metabolism in Parkinson's disease: a possible novel therapeutic approach. | |
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MedLine Citation:
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PMID: 21824629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parkinson's disease (PD) is one of the most common disabling neurodegenerative diseases. Although several therapeutic approaches are available, there are two major unresolved issues: the lack of proved neuroprotective therapy and the treatment of L-dopa-induced motor complications. In the brain, 90% of the tryptophan is metabolized in the kynurenine pathway. Some of the intermediates, such as quinolinic acid and 3-hydroxy kynurenine, are neurotoxic, while others, such as kynurenic acid, are putative intrinsic neuroprotective compounds, mainly by acting as endogenous antagonists of ionotropic excitatory amino acid receptors. Alterations in the kynurenine pathway have been demonstrated in PD. Preclinical data suggest that intervention in the kynurenine pathway may result in neuroprotection and may alleviate L-dopa-induced dyskinesia. There are two alternative approaches for such intervention: the use of kynurenic acid analogues or pro-drugs, or modulation of the activities of the intrinsic enzymes of the pathway. |
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Authors:
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Nikoletta Szabó; Zsigmond Tamás Kincses; József Toldi; Laszló Vécsei |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-08-06 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 310 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-17 Completed Date: 2012-02-16 Revised Date: 2012-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 256-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiparkinson Agents
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adverse effects Humans Kynurenine / metabolism Levodopa / adverse effects Parkinson Disease / drug therapy, metabolism* Tryptophan / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Levodopa; 343-65-7/Kynurenine; 73-22-3/Tryptophan |
| Comments/Corrections | |
Comment In:
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J Neurol Sci. 2012 Apr 15;315(1-2):180; author reply 181-2
[PMID:
22169632
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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