Document Detail


Altered tissue metabolism of progesterone in pregnancy gingivitis and granuloma.
MedLine Citation:
PMID:  1856307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of progesterone may play a special role in the gingival physiology. The lower the metabolism the higher its hormonal activity in the tissue. In healthy human gingiva, progesterone is metabolized only partially and is therefore in an active form. In the present study, gingival samples from pregnancy gingivitis (n = 1) and granulomas (n = 4) were studied histologically and biochemically. All samples were homogenized and then incubated with [4-14C]-progesterone and NADPH for 2 h at pH 7.4 and 37 degrees C. The metabolites were separated and characterized with column, solvent and thin-layer chromatographies as well as radioautography and quantified with liquid scintillation counting. The results showed low metabolism of progesterone, indicating active hormonal function as in healthy gingiva. It is suggested that progesterone functions as an immunosuppressant in the gingival tissues of pregnant women, preventing the rapid acute-type of inflammatory reaction against plaque, but allowing an increased chronic-type of tissue reaction, resulting clinically in an exaggerated appearance of inflammation.
Authors:
A O Ojanotko-Harri; M P Harri; H M Hurttia; L A Sewón
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  18     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  262-6     Citation Subset:  D; IM    
Affiliation:
Department of Physiology, University of Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
5-alpha-Dihydroprogesterone
Adult
Autoradiography
Carbon Radioisotopes / diagnostic use
Chromatography
Epithelium / pathology
Female
Gingival Diseases / complications,  metabolism*,  pathology
Gingivitis / complications,  metabolism*,  pathology
Granuloma / complications,  metabolism*,  pathology
Humans
Pregnancy
Pregnancy Complications / metabolism*,  pathology
Pregnanediones / metabolism
Progesterone / metabolism*
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Pregnanediones; 566-65-4/5-alpha-Dihydroprogesterone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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