Document Detail

Altered thyroid hormone levels in bacterial sepsis: the role of nutritional adequacy.
MedLine Citation:
PMID:  7421584     Owner:  NLM     Status:  MEDLINE    
Depressed triiodothyronine and elevated reverse triiodothyronine levels are commonly seen in patients with acute and chronic illness and in patients receiving markedly hypocaloric diets. To investigate the role of nutritional adequacy in causing the altered thyroid hormone levels found in severe illness, we studied patients with bacterial sepsis who were receiving a variety of nutritional regimens. Thirteen patients received only 5% dextrose in water (600-1000 kcal/day), 7 of whom were in shock. Seven patients received total parenteral nutrition (2500-3500 kcal/day). Analysis of thyroid hormone levels in these groups and in controls shows that a large component of the alteration in thyroid hormone levels found in patients with severe illness is due to the caloric deprivation associated with such severe illness.
D A Richmand; M E Molitch; T F O'Donnell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  29     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  936-42     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Bacteria / isolation & purification
Chronic Disease
Middle Aged
Nutritional Physiological Phenomena*
Sepsis / blood*
Thyrotropin / blood*
Thyroxine / blood*
Triiodothyronine / blood*
Triiodothyronine, Reverse / blood*
Grant Support
Reg. No./Substance:
5817-39-0/Triiodothyronine, Reverse; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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