Document Detail


Altered susceptibility of 2f1-f2 acoustic-distortion products to the effects of repeated noise exposure in rabbits.
MedLine Citation:
PMID:  1880074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hearing sensitivity and the generation of acoustic-distortion products at 2f1-f2 were examined systematically in behaviorally trained rabbits, before, during, and following regular exposure to a 95-dB SPL octave band of noise, centered at 1 kHz. During the exposure period, the octave-band noise was interrupted once every 24 h in order to monitor the progressive loss in auditory function using tests of behavioral threshold and distortion-product otoacoustic emissions (DPOAEs). When low-frequency DPOAEs from 1-4 kHz diminished to noise-floor levels, i.e., when their amplitudes were reduced by about 20-30 dB, the exposure was terminated. Subsequent recovery of behavioral thresholds and DPOAE amplitudes and detection 'thresholds' was evaluated at regular intervals over a 3-week post-exposure period. Following the recovery period, the rabbits again received the identical exposure/recovery treatment until a permanent 10 dB or greater loss in DPOAE amplitudes was achieved for any point of measurement between 2-10 kHz. The primary result was that the number of days of overstimulation required for rabbits to reach the criterion loss in DPOAE amplitudes increased for each successive exposure session. In addition, DPOAEs accurately tracked the frequency pattern described by the behavioral threshold shifts during both the development and recovery stages of exposure.
Authors:
D J Franklin; B L Lonsbury-Martin; B B Stagner; G K Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  53     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-09-30     Completed Date:  1991-09-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  185-208     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas.
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MeSH Terms
Descriptor/Qualifier:
Animals
Audiometry
Behavior, Animal
Ear / physiology*
Noise*
Perceptual Distortion / physiology*
Rabbits
Sensory Thresholds
Time Factors
Grant Support
ID/Acronym/Agency:
DC00313/DC/NIDCD NIH HHS; DC00613/DC/NIDCD NIH HHS; ES03500/ES/NIEHS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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