| Altered subcellular and submitochondrial localization of CTP:phosphatidate cytidylyltransferase in the Morris 7777 hepatoma. | |
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MedLine Citation:
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PMID: 209110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The subcellular and submitochondrial localization of CTP:phosphatidate cytidylyltransferase is altered in the Morris 7777 hepatoma. Mitochondria in this poorly differentiated tumor are the principal sites of CDP-diacylglycerol synthesis, in contrast to normal rat liver where the endoplasmic reticulum is most active. This enzyme activity was increased 17-fold in the outer mitochondrial membrane, and a 22% increase was noted in the inner mitochondrial membrane of the 7777 hepatoma as compared with the corresponding fractions from normal rat liver. Increased mitochondrial CTP:phosphatidate cytidylyltransferase was present in six other Morris hepatomas, but it was not found in fetal rat liver mitochondria, suggesting that rapid growth alone is not responsible for the difference. Evidence is presented which indicates that mitochondrial lipid degradation is similar in normal liver and the 7777 hepatoma, in vitro. The increased activity of CTP: phosphatidate cytidylytransferase is thought to be responsible in part for the moderately increased diphosphatidylglycerol content of 7777 hepatoma mitochondria. |
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Authors:
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K Y Hostetler; B D Zenner; H P Morris |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of lipid research Volume: 19 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1978-09-30 Completed Date: 1978-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 553-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / enzymology* Cardiolipins / metabolism Cytidine Diphosphate Diglycerides Liver Neoplasms Male Microsomes, Liver / enzymology Mitochondria / enzymology* Mitochondria, Liver / enzymology Neoplasms, Experimental / enzymology* Nucleotidyltransferases / analysis*, metabolism Rats |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Cytidine Diphosphate Diglycerides; EC 2.7.7.-/Nucleotidyltransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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