| Altered structure of autoantigens during apoptosis. | |
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MedLine Citation:
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PMID: 15261336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clustering and concentration of autoantigens at the surface of apoptotic cells, in combination with the striking tolerance-inducing function of apoptotic cells, have focused attention on abnormalities in apoptotic cell execution and clearance as potential susceptibility and initiating factors in systemic autoimmunity. Structural changes that occur during cell death may influence the immunogenicity of self antigens. This article discusses the modifications that autoantigens undergo during cell death, identifies certain proimmune forms of apoptotic death in which autoantigen structure is frequently modified, and reviews the mechanisms through which such structural changes might lead to initiation of an autoimmune response. |
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Authors:
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John C Hall; Livia Casciola-Rosen; Antony Rosen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Rheumatic diseases clinics of North America Volume: 30 ISSN: 0889-857X ISO Abbreviation: Rheum. Dis. Clin. North Am. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-20 Completed Date: 2004-09-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8708093 Medline TA: Rheum Dis Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 455-71, vii Citation Subset: IM |
Affiliation:
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Department of Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason F. Lord Building, Center Tower, Suite 5300, Baltimore, MD 21224, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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immunology* Autoantibodies / immunology Autoantigens / immunology* Autoimmune Diseases / immunology Humans |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Autoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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