Document Detail

Altered spermatogenesis in the hypodactylous rats.
MedLine Citation:
PMID:  15744379     Owner:  NLM     Status:  MEDLINE    
Germinal epithelium of seminiferous tubules in adult, infertile hypodactylous males displays significant reduction in the number of germ-line cells. Detection of apoptosis in the germ-line cells during postnatal differentiation was performed to elucidate the mechanism of the decreased number of germ cells in the testes of adult rats. Evaluation of DNA fragmentation and expression of activated caspase-3 in germ cells did not confirm marked germ cell death during the onset of spermatogenesis as a main cause of significant reduction of germ cells in Hd/Hd testes of adult males. The primary cause of spermatogenesis defect seems to be rather associated with a disorder in the cell cycle regulation and interrelation of germ-line cells with Sertoli cells.
Zuzana Jirsová; Tomás Kucera; Jindrich Martínek; Frantisek Liska; Drahomíra Krenová; Vladimír Kren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia     Volume:  148     ISSN:  1213-8118     ISO Abbreviation:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2006-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140142     Medline TA:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  213-5     Citation Subset:  IM    
Institute of Histology and Embryology, 1st Faculty of Medicine, Charles University, Albertov 4, Prague 2, 128 01, Czech Republic.
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MeSH Terms
Infertility, Male / pathology,  physiopathology*
Rats, Mutant Strains
Testis / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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