Document Detail


Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart.
MedLine Citation:
PMID:  20483313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (DeltaPsi(m)) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of DeltaPsi(m) within the intact heart during ischemia-reperfusion injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate DeltaPsi(m) spatiotemporal properties and arrhythmia propensity.
Authors:
Hongwei Jin; Robert D Nass; Paul J Joudrey; Alexander R Lyon; Elie R Chemaly; Kleopatra Rapti; Fadi G Akar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biophysical journal     Volume:  98     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-09-15     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2063-71     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Affiliation:
Cardiovascular Research Center, Division of Cardiology, Mount Sinai School of Medicine, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / physiopathology*
Cardiomegaly / physiopathology*
Disease Models, Animal
Male
Membrane Potential, Mitochondrial / physiology*
Mitochondria, Heart
Myocytes, Cardiac / pathology*
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species / metabolism*
Reperfusion Injury / physiopathology
Grant Support
ID/Acronym/Agency:
HL091923/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species
Comments/Corrections

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