| Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart. | |
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MedLine Citation:
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PMID: 20483313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (DeltaPsi(m)) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of DeltaPsi(m) within the intact heart during ischemia-reperfusion injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate DeltaPsi(m) spatiotemporal properties and arrhythmia propensity. |
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Authors:
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Hongwei Jin; Robert D Nass; Paul J Joudrey; Alexander R Lyon; Elie R Chemaly; Kleopatra Rapti; Fadi G Akar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biophysical journal Volume: 98 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-09-15 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
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Languages: eng Pagination: 2063-71 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Cardiovascular Research Center, Division of Cardiology, Mount Sinai School of Medicine, New York, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / physiopathology* Cardiomegaly / physiopathology* Disease Models, Animal Male Membrane Potential, Mitochondrial / physiology* Mitochondria, Heart Myocytes, Cardiac / pathology* Rats Rats, Sprague-Dawley Reactive Oxygen Species / metabolism* Reperfusion Injury / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL091923/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species |
| Comments/Corrections | |
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