| Altered small artery morphology and reactivity in critical limb ischaemia. | |
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MedLine Citation:
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PMID: 9918895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the pathophysiology of critical limb ischaemia is poorly understood, there is evidence that the condition of the small arteries may determine the outcome of revascularization procedures. This study was designed to investigate the effects of critical limb ischaemia on the structure and function of the small arteries in the leg. Small arteries (<500 microm) from proximal (non-ischaemic) and distal (ischaemic) sites were obtained from patients undergoing bypass surgery for critical limb ischaemia and mounted in a myograph. Reactivity and morphological measurements were carried out and compared with controls. Control vessels from the thigh and calf showed no difference in media to lumen ratio. However, a comparison of ischaemic and non-ischaemic vessels from the patients with critical limb ischaemia showed significant thinning of the ischaemic vessel wall. Contraction studies using noradrenaline and angiotensin II revealed a significant decrease in the response of ischaemic vessels compared with the non-ischaemic vessels from the same patient. Moreover, these differences in reactivity were still apparent after the responses were corrected for wall thickness. Endothelial function assessed using the endothelium-dependent agonists acetylcholine and bradykinin showed a significantly impaired relaxation response to acetylcholine but not to bradykinin in the ischaemic vessels, and acetylcholine-induced relaxation was not improved after incubation with indomethacin. There was no change in the response to the endothelium-independent cAMP-mediated vasodilator iloprost but a significant impairment to sodium nitroprusside which acts via cGMP. These results suggest that small arteries in critical limb ischaemia are altered in both structure and function, with vessel wall thinning and impaired responses to acetylcholine and sodium nitroprusside. |
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Authors:
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C Hillier; R D Sayers; P A Watt; R Naylor; P R Bell; H Thurston |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 96 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-04-15 Completed Date: 1999-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 155-63 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Faculty of Health, Glasgow Caledonian University, Glasgow G4 OBA, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Aged Analysis of Variance Angiotensin II / pharmacology Arteries / drug effects, pathology, physiopathology Bradykinin / pharmacology Dose-Response Relationship, Drug Endothelium, Vascular / drug effects Female Humans Iloprost / pharmacology Ischemia / pathology*, physiopathology Leg / blood supply* Male Middle Aged Muscle, Smooth, Vascular / drug effects Nitroprusside / pharmacology Norepinephrine / pharmacology Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 0/Vasodilator Agents; 11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 58-82-2/Bradykinin; 78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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