| Altered sensorimotor responses to esophageal acidification in older adults with GERD. | |
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MedLine Citation:
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PMID: 20545468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study aimed to compare the effect of intraluminal acidification on esophageal sensory perception and motor activity between older and younger patients with gastroesophageal reflux disease (GERD). MATERIAL AND METHODS: All 40 subjects had saline and hydrochloric acid infused into the mid-esophagus. The esophageal perception to acid infusion was documented including lag time, intensity rating, and sensitivity score. Esophageal body motility was recorded. RESULTS: The younger group had a shorter lag time to initial heartburn perception (p = 0.01) and a greater sensory intensity rating (p = 0.001). The acid infusion sensitivity score was lower in the older patients (p = 0.001). Age positively correlated to lag time to initial symptom perception (r = 0.44, p = 0.005), but negatively correlated to sensory intensity (r = -0.40, p = 0.01) and acid infusion sensitivity score (r = -0.39, p = 0.01). When compared with saline infusion, acid infusion induced a significant increase in the deglutition frequency in younger patients (0.51 vs. 0.67, p = 0.005), but not in older patients (0.59 vs. 0.65, p = 0.67). CONCLUSIONS: Age-related decrease in sensorimotor response to esophageal acidification may be an important element in the pathogenesis and clinical presentation of GERD in older adults. |
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Authors:
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Chien-Lin Chen; Chih-Hsun Yi; Tso-Tsai Liu; William C Orr |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 45 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: England |
Other Details:
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Languages: eng Pagination: 1150-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan. harry.clchen@msa.hinet.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aging / metabolism* Esophageal pH Monitoring* Esophagoscopy Esophagus / drug effects* Female Gastroesophageal Reflux / diagnosis, metabolism, physiopathology* Heartburn / physiopathology* Humans Hydrochloric Acid / administration & dosage* Male Manometry Middle Aged Pain Threshold* Peristalsis Predictive Value of Tests Risk Assessment Risk Factors Severity of Illness Index Sodium Chloride / administration & dosage* Time Factors |
| Chemical | |
Reg. No./Substance:
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7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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