Document Detail


Altered salivary profile in heavy smokers and its possible connection to oral cancer.
MedLine Citation:
PMID:  18161658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Saliva is the first biological fluid to encounter inhaled cigarette smoke, whose numerous carcinogens and oxidants are responsible for the oral cancer so prevalent among smokers. Whole saliva, collected from 25 consenting heavy smokers and from a control group of 25 age- and gender-matched non-smokers, was subjected to sialochemical, biochemical, immunological and oxidative analyses. The mean flow rate was significantly higher in smokers than in non-smokers, as were the median activity value of superoxide dismutase (SOD) and the total salivary antioxidant capacity (ImAnOx) (by 32% and 12%, respectively, p=0.05). The salivary carbonyl concentration (an oxidative stress indicator) was significantly higher by 126% (p=0.0006) among smokers, while lactate dehydrogenase, albumin, total immunoglobulin G, and the metalloproteinases MMP-2 and MMP-9 concentrations were significantly lower in the smokers, by 86% (p=0.003), 65% (p=0.003), 61% (p=0.048), 35% (p=0.005) and 55% (p=0.035), respectively. Apparently, the oral cavity''s salivary antioxidant system fails to cope with the severe attack of reactive oxygen species originating in cigarette smoke. Moreover, various other salivary functional and protective parameters also decreased among the smokers. Hence, further research aimed at examining the possibility of administration of agents as antioxidants or saliva substitutes to the oral cavity of smokers should be considered.
Authors:
R M Nagler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of biological markers     Volume:  22     ISSN:  0393-6155     ISO Abbreviation:  Int. J. Biol. Markers     Publication Date:    2007 Oct-Dec
Date Detail:
Created Date:  2007-12-28     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  274-80     Citation Subset:  IM    
Affiliation:
Department of Oral & Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. nagler@tx.technion.ac.il
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MeSH Terms
Descriptor/Qualifier:
Aged
Antioxidants / metabolism
Case-Control Studies
Electrolytes
Female
Humans
Male
Middle Aged
Mouth Neoplasms / etiology*,  metabolism*
Oxidative Stress
Oxygen / metabolism
Peroxidase / metabolism
Saliva / metabolism*
Smoking*
Uric Acid / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Electrolytes; 69-93-2/Uric Acid; 7782-44-7/Oxygen; EC 1.11.1.7/Peroxidase

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