Document Detail

Altered rheological properties of blood following administrations of tissue plasminogen activator and streptokinase in patients with acute myocardial infarction.
MedLine Citation:
PMID:  2129379     Owner:  NLM     Status:  MEDLINE    
Tissue blood flow is determined by rheological properties of blood as well as by vascular resistance. In acute myocardial infarction patients who participated in the TIMI I trial, we compared the effects of recombinant tissue plasminogen activator (rt-PA) and streptokinase (SK) on blood rheological properties and plasma fibrinogen concentration. Blood viscosity was determined by using a coaxial cylinder viscometer at shear rates, gamma, of 0.01-200 sec-1. Red blood cell (RBC) deformability was studied by filtration through polycarbonate microsieves with pore size of 3 and 5 microns. Therapy with rt-PA resulted in slight decreases but statistically significant in blood viscosity from 5.2 +/- 0.5 to 4.9 +/- 0.4 cP (gamma = 52 sec-1), plasma viscosity from 1.36 +/- 0.09 to 1.32 +/- 0.06 cP, and plasma fibrinogen from 0.26 +/- 0.04 to 0.21 +/- 0.03 g/dl. SK therapy resulted in reductions in blood viscosity from 5.1 +/- 0.5 to 4.6 +/- 0.3 cP, plasma viscosity from 1.26 +/- 0.10 to 1.16 +/- 0.03 cP, and fibrinogen from 0.26 +/- 0.06 to 0.10 +/- 0.05 g/dl. Changes observed with SK were significantly greater than those observed with rt-PA (all p less than 0.05), and the differences persisted at 10 days after thrombolytic therapy. RBC deformability was similar in the two groups. The greater reduction of blood viscosity after SK than rt-PA suggests that, for a given degree of arterial patency, myocardial blood flow may be better maintained with SK than rt-PA in patients with acute myocardial infarction.
K M Jan; E Powers; W Reinhart; A Berke; A Nichols; R Watson; D Reison; A Schwartz; S Chien
Related Documents :
14615279 - Radial displacement of red blood cells during hemodilution and the effect on arteriolar...
17066169 - Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels.
1275089 - Influence of blood rheology on intrarenal blood flow distribution.
2129379 - Altered rheological properties of blood following administrations of tissue plasminogen...
1143159 - Elevation of blood viscosity, aggregation of red cells, haematocrit values and fibrinog...
10856629 - Ultrasonic wave action upon the red blood cell agglutination in vitro.
5312499 - The role of chronic blood loss in the pathogenesis of postgastrectomy iron-deficiency a...
5807219 - The effects of time-varying blood flow on diffusional resistance to oxygen transfer in ...
6862789 - The detection of fibrinogen (or fgdp)-protamine sulphate complex in vitro and in the ci...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  281     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-09-24     Completed Date:  1991-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-17     Citation Subset:  IM    
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Proteins / analysis
Blood Viscosity
Erythrocyte Count
Hemoglobins / analysis
Leukocyte Count
Middle Aged
Myocardial Infarction / blood*,  drug therapy,  physiopathology
Recombinant Proteins / therapeutic use
Streptokinase / therapeutic use*
Tissue Plasminogen Activator / therapeutic use*
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins; 0/Recombinant Proteins; EC 3.4.-/Streptokinase; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modern strategies for treatment of acute myocardial infarction: significance of haemostaseological a...
Next Document:  Laser applications in cosmetic surgery.