| Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM). | |
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MedLine Citation:
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PMID: 6808626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Respiratory studies were conducted on newborn puppies chronically exposed to alpha-l-acetylmethadol . HCl (LAAM) during portions of gestation. Bitches received daily oral doses of LAAM from the second week through the sixth week of pregnancy (LAAM-6) or through the end of a 9-week pregnancy (LAAM-9), but not after parturition. LAAM-9 pups displayed narcotic abstinence signs during the first week after birth, while LAAM-6 pups did not. LAAM-9 pups had increased tidal volume, respiratory frequency, alveolar ventilation and O2-consumption and decreased alveolar CO2-tension during the first week of life compared to placebo-treated controls. The LAAM-9 CO2-response curve was significantly displaced to the left of control. These data are consistent with relative hyperventilation during neonatal withdrawal from LAAM. LAAM-6 pups had decreased tidal volume and alveolar ventilation during 4 of the 6 weeks studied. These changes in ventilation were associated with a decrease in O2 consumption. By 6 weeks after birth CO2-response curves of both LAAM-9 and LAAM-6 pups were shifted to the right of control. These changes in CO2-responsiveness suggest the possibility of prolonged disturbances of respiratory control which may continue beyond the sixth week of life. |
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Authors:
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K L McGillkiard; S E Jones; G E Robertson; G D Olsen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiration physiology Volume: 47 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 299-311 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Carbon Dioxide / pharmacology Chloral Hydrate / pharmacology Dogs Female Humans Methadone / analogs & derivatives* Methadyl Acetate / pharmacology* Pregnancy Prenatal Exposure Delayed Effects* Respiration / drug effects* Sleep / drug effects, physiology Substance Withdrawal Syndrome / physiopathology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD-10034/HD/NICHD NIH HHS; HL-05918/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 302-17-0/Chloral Hydrate; 509-74-0/Methadyl Acetate; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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