Document Detail


Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM).
MedLine Citation:
PMID:  6808626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Respiratory studies were conducted on newborn puppies chronically exposed to alpha-l-acetylmethadol . HCl (LAAM) during portions of gestation. Bitches received daily oral doses of LAAM from the second week through the sixth week of pregnancy (LAAM-6) or through the end of a 9-week pregnancy (LAAM-9), but not after parturition. LAAM-9 pups displayed narcotic abstinence signs during the first week after birth, while LAAM-6 pups did not. LAAM-9 pups had increased tidal volume, respiratory frequency, alveolar ventilation and O2-consumption and decreased alveolar CO2-tension during the first week of life compared to placebo-treated controls. The LAAM-9 CO2-response curve was significantly displaced to the left of control. These data are consistent with relative hyperventilation during neonatal withdrawal from LAAM. LAAM-6 pups had decreased tidal volume and alveolar ventilation during 4 of the 6 weeks studied. These changes in ventilation were associated with a decrease in O2 consumption. By 6 weeks after birth CO2-response curves of both LAAM-9 and LAAM-6 pups were shifted to the right of control. These changes in CO2-responsiveness suggest the possibility of prolonged disturbances of respiratory control which may continue beyond the sixth week of life.
Authors:
K L McGillkiard; S E Jones; G E Robertson; G D Olsen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  47     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  299-311     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Carbon Dioxide / pharmacology
Chloral Hydrate / pharmacology
Dogs
Female
Humans
Methadone / analogs & derivatives*
Methadyl Acetate / pharmacology*
Pregnancy
Prenatal Exposure Delayed Effects*
Respiration / drug effects*
Sleep / drug effects,  physiology
Substance Withdrawal Syndrome / physiopathology
Time Factors
Grant Support
ID/Acronym/Agency:
HD-10034/HD/NICHD NIH HHS; HL-05918/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 302-17-0/Chloral Hydrate; 509-74-0/Methadyl Acetate; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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