Document Detail

Altered regulation of cell surface peptidases in human cholesteatoma.
MedLine Citation:
PMID:  9018259     Owner:  NLM     Status:  MEDLINE    
Cholesteatoma is a destructive process involving an accumulation of desquamated keratin arising from squamous epithelium that pathologically has invaded the middle ear or mastoid process. The clinical hallmarks of cholesteatomas, namely invasion of healthy tissues, migration, unrestrained proliferation, aggressiveness, recidivism, and uncoordinated differentiation predict the existence of defects in the normal biology and biochemistry of the cellular constituents that compose a cholesteatoma, as well as in the cellular interactions between these cells, the surrounding normal tissue, and the host. In the current report, we analyzed 11 cholesteatomas and matched healthy tissue for altered expression in four different cell surface peptidases, aminopeptidase A, aminopeptidase N, dipeptidyl peptidase IV, and neutral endopeptidase. We suggest that peptidases may modulate cell growth and differentiation by inactivating stimulatory signals (or conversely, by activating inhibitory signals).
R B Desloge; C L Finstad; J Sassoon; J C Han; S C Parisier; A P Albino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  116     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-02-26     Completed Date:  1997-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  58-63     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Manhattan Eye, Ear, and Throat Hospital, New York, NY 10021, USA.
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MeSH Terms
Aminopeptidases / metabolism
Antibodies, Monoclonal
Antigens, CD13 / metabolism
Antigens, CD26 / metabolism
Child, Preschool
Cholesteatoma, Middle Ear / metabolism*,  pathology
Glutamyl Aminopeptidase
Membrane Proteins / metabolism*
Middle Aged
Neprilysin / metabolism
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Membrane Proteins; EC 3.4.11.-/Aminopeptidases; EC, CD13; EC Aminopeptidase; EC, CD26; EC
Erratum In:
Otolaryngol Head Neck Surg 1997 Mar;116(3):418

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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