| Altered purine nucleotide degradation during exercise in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 11398139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Purine degradation occurs during strenuous muscle exercise and plasma levels of hypoxanthine (HX), purine degradation intermediate, increase. Purine nucleotide degradation has not been investigated in patients with essential hypertension (HTN). The present study determined whether purine nucleotide degradation is altered in patients with HTN. Cardiopulmonary exercise test was performed with serial measurements in blood lactate and plasma HX in 24 patients (14 men and 10 women) with essential HTN (World Health Organization [WHO] class I to II; mean age, 57.7 +/- 2.1 years) and 24 age-, sex-matched normal subjects. Exercise was terminated either by severe fatigue or excess blood pressure increase. Peak work rate (WR) (normal v HTN, 151 +/- 10 v 135 +/- 8 W, not significant [NS]) was not different, but peak oxygen uptake (peak Vo(2), 26.3 +/- 1.5 v 22.2 +/- 0.9 mL/min/kg, P <.05) and anaerobic threshold were lower in patients with HTN. Resting levels of blood lactate and plasma HX were similar, but the increment from rest to peak exercise (Delta) for lactate (Delta lactate: 4.4 +/- 0.4 v 3.4 +/- 0.4 mmol/L, P <.05) and for HX (Delta HX, 15.9 +/- 2.2 v 9.1 +/- 1.1 micromol/L, P <.05) were significantly smaller in patients with HTN. When normalized by the peak WR, Delta HX/peak WR (0.105 +/- 0.013 v 0.069 +/- 0.007 micromol/L/W, P <.05) was significantly lower in patients with HTN. Patients with HTN exhibited reduced HX response to exercise with impaired exercise capacity. The exercise-induced changes in plasma HX were smaller in patients with HT when normalized with peak WR. These results suggest that the purine nucleotide degradation is reduced in patients with HTN. |
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Authors:
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T Kinugawa; K Ogino; S Osaki; M Kato; A Endo; T Hamada; Y Honami; O Igawa; I Hisatome; C Shigemasa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 50 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-08 Completed Date: 2001-07-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 646-50 Citation Subset: IM |
Copyright Information:
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Copyright 2001 by W.B. Saunders Company |
Affiliation:
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Division of Cardiology, The First Department of Internal Medicine, Tottori University Faculty of Medicine, Yonago, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Exercise Test* Female Humans Hypertension / blood, metabolism, physiopathology* Hypoxanthine / blood Lactic Acid / blood Male Middle Aged Purine Nucleotides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Purine Nucleotides; 50-21-5/Lactic Acid; 68-94-0/Hypoxanthine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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