Document Detail


Altered purine nucleotide degradation during exercise in patients with essential hypertension.
MedLine Citation:
PMID:  11398139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Purine degradation occurs during strenuous muscle exercise and plasma levels of hypoxanthine (HX), purine degradation intermediate, increase. Purine nucleotide degradation has not been investigated in patients with essential hypertension (HTN). The present study determined whether purine nucleotide degradation is altered in patients with HTN. Cardiopulmonary exercise test was performed with serial measurements in blood lactate and plasma HX in 24 patients (14 men and 10 women) with essential HTN (World Health Organization [WHO] class I to II; mean age, 57.7 +/- 2.1 years) and 24 age-, sex-matched normal subjects. Exercise was terminated either by severe fatigue or excess blood pressure increase. Peak work rate (WR) (normal v HTN, 151 +/- 10 v 135 +/- 8 W, not significant [NS]) was not different, but peak oxygen uptake (peak Vo(2), 26.3 +/- 1.5 v 22.2 +/- 0.9 mL/min/kg, P <.05) and anaerobic threshold were lower in patients with HTN. Resting levels of blood lactate and plasma HX were similar, but the increment from rest to peak exercise (Delta) for lactate (Delta lactate: 4.4 +/- 0.4 v 3.4 +/- 0.4 mmol/L, P <.05) and for HX (Delta HX, 15.9 +/- 2.2 v 9.1 +/- 1.1 micromol/L, P <.05) were significantly smaller in patients with HTN. When normalized by the peak WR, Delta HX/peak WR (0.105 +/- 0.013 v 0.069 +/- 0.007 micromol/L/W, P <.05) was significantly lower in patients with HTN. Patients with HTN exhibited reduced HX response to exercise with impaired exercise capacity. The exercise-induced changes in plasma HX were smaller in patients with HT when normalized with peak WR. These results suggest that the purine nucleotide degradation is reduced in patients with HTN.
Authors:
T Kinugawa; K Ogino; S Osaki; M Kato; A Endo; T Hamada; Y Honami; O Igawa; I Hisatome; C Shigemasa
Related Documents :
22455089 - In adults with atrial switch operation for transposition of the great arteries low phys...
19948679 - Is lactate production related to muscular fatigue? a pedagogical proposition using empi...
3884959 - Anaerobic threshold: review of the concept and directions for future research.
10776889 - Cardiorespiratory and metabolic responses to exercise in hbsc sickle cell patients.
1917759 - Decreased reliance on lactate during exercise after acclimatization to 4,300 m.
14998099 - Maximal lactate steady state in trained adolescent runners.
18644399 - Fitness alters fluid regulatory but not behavioural responses to hypohydrated exercise.
3877549 - Exercise physiology. an overview.
6728889 - Studies on the release of solubilized drugs from ointment bases. part 8: the effect of ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  50     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-08     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  646-50     Citation Subset:  IM    
Copyright Information:
Copyright 2001 by W.B. Saunders Company
Affiliation:
Division of Cardiology, The First Department of Internal Medicine, Tottori University Faculty of Medicine, Yonago, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Exercise Test*
Female
Humans
Hypertension / blood,  metabolism,  physiopathology*
Hypoxanthine / blood
Lactic Acid / blood
Male
Middle Aged
Purine Nucleotides / metabolism*
Chemical
Reg. No./Substance:
0/Purine Nucleotides; 50-21-5/Lactic Acid; 68-94-0/Hypoxanthine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Factors explaining the difference of total homocysteine between men and women in the European Invest...
Next Document:  Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and ...