Document Detail


Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients.
MedLine Citation:
PMID:  17039242     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Involved regions of the skin in atopic dermatitis (AD) patients have an altered barrier function. Whether uninvolved skin also has a diminished barrier is controversial. To assess the barrier function of uninvolved skin in AD patients, the percutaneous penetration of polyethylene glycols (PEGs) of various molecular sizes was determined in vivo in AD patients and control subjects using tape stripping of the stratum corneum (SC). The diffusion and partition coefficients were determined using Fick's second law of diffusion. The SC thickness was similar in both groups; however, the trans-epidermal water loss was higher in atopic skin. The apparent diffusion coefficient of PEGs through atopic skin was twice as high as through normal skin, and decreased with increasing molecular weight (MW) in both groups. The partition coefficient in the skin of AD patients was half of that for normal skin but as for normal skin, there was no MW dependency. Although atopic skin exhibited altered barrier with respect to diffusion and partitioning, the permeability coefficients were nearly the same for atopic and normal skin. The results support the assumption of altered skin barrier of AD patients even in the skin that is visibly unaffected by disease.
Authors:
Ivone Jakasa; Maarten M Verberk; Maria Esposito; Jan D Bos; Sanja Kezic
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-12
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  127     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Affiliation:
Department: Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. i.jakasa@amc.uva.nl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Dermatitis, Atopic / metabolism*
Diffusion
Female
Humans
Male
Middle Aged
Permeability
Polyethylene Glycols / chemistry,  pharmacokinetics*
Skin / metabolism*
Chemical
Reg. No./Substance:
0/Polyethylene Glycols
Comments/Corrections
Comment In:
J Invest Dermatol. 2007 Jan;127(1):8-10   [PMID:  17170718 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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