Document Detail


Altered oxidative stress in overtrained athletes.
MedLine Citation:
PMID:  20077275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present study was to examine the relationship between oxidative stress and overtraining syndrome. Indicators of oxidative stress (plasma protein carbonyls, nitrotyrosine, and malondialdehyde) and antioxidant status (oxygen radical absorbance capacity) were measured in severely overtrained (two women, five men) and control athletes (five women, five men). Samples were collected from both groups at baseline (i.e. in the overtraining state of overtrained athletes) and after 6 months of recovery, both at rest and immediately after an exercise test to volitional exhaustion. At baseline, overtrained athletes had higher plasma protein carbonyls at rest than controls (mean difference 0.03 nmol . mg(-1), 95% CI = 0.01-0.05 nmol . mg(-1), P = 0.003, effect size = 0.40). Both at baseline and after recovery, exercise to exhaustion led to an increase in oxygen radical absorbance capacity and malondialdehyde (P = 0.001-0.006) in the controls but not in the overtrained athletes. Furthermore, at baseline, only overtrained athletes showed negative correlations between oxygen radical absorbance capacity at rest and protein carbonyls after exhaustive exercise (r = -0.98, P = 0.0001). These results suggest that increased oxidative stress has a role in the pathophysiology of overtraining syndrome. The attenuated responses of oxidative stress and antioxidant capacity to exercise in the overtrained state could be related to an inability to perform exercise effectively and impaired adaptation to exercise.
Authors:
Minna Tanskanen; Mustafa Atalay; Arja Uusitalo
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of sports sciences     Volume:  28     ISSN:  1466-447X     ISO Abbreviation:  J Sports Sci     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405364     Medline TA:  J Sports Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  309-17     Citation Subset:  IM    
Affiliation:
Department of Biology of Physical Activity, University of Jyväskylä, Kidekuja 2, Snowpolis, Jyväskylä, Finland. minna.m.tanskanen@jyu.fi
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Athletes*
Blood Proteins
Exercise / physiology*
Fatigue / physiopathology*
Female
Humans
Male
Malondialdehyde / blood
Oxidative Stress / physiology*
Physical Endurance / physiology*
Physical Fitness / physiology*
Protein Carbonylation*
Reactive Oxygen Species / metabolism
Rest
Young Adult
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Reactive Oxygen Species; 542-78-9/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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