| Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension. | |
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MedLine Citation:
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PMID: 17558095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension. AIMS: The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension. MATERIALS AND METHODS: Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups. STATISTICAL ANALYSIS: Results were analyzed by student's 't' test and linear regression analysis test. RESULTS: Plasma protein carbonyl and glutathione peroxidase were significantly increased and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group. CONCLUSIONS: The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension. |
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Authors:
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H Nandeesha; V Sathiyapriya; Zachariah Bobby; P Pavithran; Aparna Agrawal; N Selvaraj |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of medical sciences Volume: 61 ISSN: 0019-5359 ISO Abbreviation: Indian J Med Sci Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2008-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373023 Medline TA: Indian J Med Sci Country: India |
Other Details:
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Languages: eng Pagination: 326-31 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / metabolism* Blood Glucose / metabolism Catalase / blood Glutathione / blood Glutathione Peroxidase / blood Humans Hypertension / blood, metabolism* Linear Models Male Obesity Oxidative Stress* Protein Carbonylation Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Blood Glucose; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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