Document Detail

Altered nitric oxide production in the premature gut may increase susceptibility to intestinal damage in necrotizing enterocolitis.
MedLine Citation:
PMID:  11329569     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: Nitric oxide (NO) mediates enteric smooth muscle relaxation and mucosal protection. The authors have identified an ontogenically determined pattern of enteric NO neural maturation that may render the distal gut of premature piglets susceptible to injury. METHODS: NO synthase (cNOS and iNOS) activities were measured in the developing piglet gut wall and compared with gut from an intraluminal model of necrotizing enterocolitis (NEC) at different times. RESULTS: In premature animals, iNOS activity was significantly higher 3 hours after NEC induction compared with similarly treated 3-day-old piglets. INOS levels continued to rise 6 hours after NEC induction in prematures. Premature animals (labor induced by prostaglandins) failed to show such a rise in iNOS. In 3 day olds, iNOS levels increased significantly 16 hours after injury compared with the 3-hour group. CONCLUSIONS: iNOS production increases in premature piglets with NEC compared with full-term NEC animals and continues to rise in the presence of intestinal damage regardless of developmental status. Maternal administration of prostaglandins attenuates this rise in iNOS activity. Elevated NO production in premature gut may contribute to increased susceptibility to damage in NEC.
M Di Lorenzo; A Krantis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  36     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-01     Completed Date:  2001-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  700-5     Citation Subset:  IM    
Copyright Information:
Copyright 2001 by W.B. Saunders Company.
Division of Pediatric General Surgery, Department of Surgery, Hôpital Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
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MeSH Terms
Age Factors
Animals, Newborn / metabolism*
Disease Models, Animal*
Disease Susceptibility
Enterocolitis, Necrotizing / metabolism*
Gestational Age
Intestinal Mucosa / metabolism*
Nitric Oxide / metabolism*
Nitric Oxide Synthase / metabolism*
Obstetric Labor, Premature / drug therapy,  metabolism*
Prostaglandins / therapeutic use
Time Factors
Reg. No./Substance:
0/Prostaglandins; 10102-43-9/Nitric Oxide; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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