| Altered long chain fatty acids composition in Duchenne muscular dystrophy erythrocytes. | |
| | |
MedLine Citation:
|
PMID: 15646823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Biochemical abnormalities, increased efflux of soluble enzymes and muscle proteins, and altered permeability of muscle membranes imply the presence of a disorganized erythrocyte membrane in Duchenne muscular dystrophy (DMD). The purpose of the present study was to investigate this hypothesis of a generalized membrane defect. MATERIALS AND METHODS: Twenty-five patients with the disease were analyzed for their erythrocyte lipid composition and for alterations in their fatty acid content compared to twenty-five healthy subjects. RESULTS: DMD patients showed a decreased concentration of total phospholipids compared to healthy volunteers, with striking fluctuations in concentrations of erythrocyte long chain fatty acids. Specifically, the unsaturated fatty acids such as oleic, linoleic and arachidonic acids were significantly decreased in the disease, whereas the saturated fatty acid, palmitic acid was increased in DMD patients compared to healthy controls. CONCLUSION: Our findings suggest an abnormal fatty acid composition and disorganization of erythrocyte membrane in patients with DMD associated with possible functional alterations. |
| | |
Authors:
|
Christina Piperi; Aggeliki Papapanagiotou; Christos Kalofoutis; Katerina Zisaki; Vasiliki Michalaki; Anna Tziraki; Anastasios Kalofoutis |
Related Documents
:
|
22510093 - A synthetic approach to diverse 3-acyltetramic acids via o- to c-acyl rearrangement and... 6860703 - Neonatal changes in fatty acid profile of phospholipids in rat heart muscle. 10961723 - Role of phospholipase a2 in cholesterol gallstone formation is associated with biliary ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: In vivo (Athens, Greece) Volume: 18 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2004 Nov-Dec |
Date Detail:
|
Created Date: 2005-01-13 Completed Date: 2005-04-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
|
Languages: eng Pagination: 799-802 Citation Subset: IM |
Affiliation:
|
Department of Biological Chemistry, University of Athens, School of Medicine, Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Erythrocyte Membrane
/
chemistry* Fatty Acids, Unsaturated / chemistry* Humans Membrane Lipids / chemistry Muscular Dystrophy, Duchenne / blood* Phospholipids / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Unsaturated; 0/Membrane Lipids; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synergistic effect of dehydroascorbic acid and mixtures with vitamin E and beta-carotene on mitomyci...
Next Document: Toxicity screening of mouthwashes in the pollen tube growth test: safety assessment of recommended d...