Document Detail


Altered liver morphology after portal vein thrombosis: not always cirrhosis.
MedLine Citation:
PMID:  18270830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The macroscopic appearance of the liver after primary portal vein thrombosis often mimics cirrhosis, despite the absence of bridging fibrosis at histology. The purpose of this study was to describe unique morphologic changes of the liver after portal venous thrombosis. A retrospective review was performed to find patients with portal vein thrombosis and a corresponding noncirrhotic liver biopsy. The CT appearance of the liver was then evaluated, and the liver was categorized as having either peripheral or central hepatic atrophy. Of 15 patients included in this study, 12 had peripheral atrophy of the liver, while the remaining three had central atrophy. We concluded that maintenance of central portal venous blood flow and resultant relative peripheral atrophy of the liver may account for a distinctive rounded configuration of the liver after acute portal vein thrombosis. Awareness of this appearance after primary portal vein thrombosis may prevent an erroneous diagnosis of cirrhosis.
Authors:
Mitchell E Tublin; Alexander J Towbin; Michael P Federle; Michael A Nalesnik
Publication Detail:
Type:  Journal Article     Date:  2008-02-14
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2784-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. tublinme@upmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Atrophy / pathology,  radiography
Biopsy
Diagnosis, Differential
Female
Humans
Liver / blood supply,  pathology*,  radiography
Liver Cirrhosis / diagnosis,  pathology,  radiography
Male
Middle Aged
Portal Vein*
Retrospective Studies
Tomography, X-Ray Computed
Venous Thrombosis / complications*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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