Document Detail

Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats.
MedLine Citation:
PMID:  22939288     Owner:  NLM     Status:  MEDLINE    
Disturbed lipid metabolism has been reported in antiretroviral-naive HIV-1-infected patients suggesting a direct effect of the virus on lipid metabolism. To test that the HIV-1 virus alone could alter lipid concentrations, we measured these concentrations in an HIV-1 transgenic (Tg) rat model of human HIV-1 infection, which demonstrates peripheral and central pathology by 7-9 months of age. Concentrations were measured in high-energy microwaved heart, brain and liver from 7-9 month-old HIV-1 Tg and wildtype rats, and in plasma from non-microwaved rats. Plasma triglycerides and liver cholesteryl ester and total cholesterol concentrations were significantly higher in HIV-1 Tg rats than controls. Heart and plasma fatty acid concentrations reflected concentration differences in liver, which showed higher n-3 and n-6 polyunsaturated fatty acid (PUFA) concentrations in multiple lipid compartments. Fatty acid concentrations were increased or decreased in heart and liver phospholipid subfractions. Brain fatty acid concentrations differed significantly between the groups for minor fatty acids such as linoleic acid and n-3 docosapentaenoic acid. The profound changes in heart, plasma and liver lipid concentrations suggest a direct effect of chronic exposure to the HIV-1 virus on peripheral lipid (including PUFA) metabolism.
Ameer Y Taha; Mireille Basselin; Epolia Ramadan; Hiren R Modi; Stanley I Rapoport; Yewon Cheon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2012-08-29
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  87     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2012 Oct-Nov
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-02-25     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  91-101     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Brain / metabolism*
Cholesterol / blood,  metabolism
Cholesterol Esters / blood,  metabolism
Fatty Acids, Unsaturated / blood
HIV-1 / genetics,  physiology*
Lipid Metabolism / genetics,  physiology*
Liver / metabolism*
Myocardium / metabolism*
Rats, Inbred F344
Rats, Transgenic
Triglycerides / blood
Grant Support
Z01 AG000151-01/AG/NIA NIH HHS
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Triglycerides; 57-88-5/Cholesterol

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