| Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats. | |
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MedLine Citation:
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PMID: 22939288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disturbed lipid metabolism has been reported in antiretroviral-naive HIV-1-infected patients suggesting a direct effect of the virus on lipid metabolism. To test that the HIV-1 virus alone could alter lipid concentrations, we measured these concentrations in an HIV-1 transgenic (Tg) rat model of human HIV-1 infection, which demonstrates peripheral and central pathology by 7-9 months of age. Concentrations were measured in high-energy microwaved heart, brain and liver from 7-9 month-old HIV-1 Tg and wildtype rats, and in plasma from non-microwaved rats. Plasma triglycerides and liver cholesteryl ester and total cholesterol concentrations were significantly higher in HIV-1 Tg rats than controls. Heart and plasma fatty acid concentrations reflected concentration differences in liver, which showed higher n-3 and n-6 polyunsaturated fatty acid (PUFA) concentrations in multiple lipid compartments. Fatty acid concentrations were increased or decreased in heart and liver phospholipid subfractions. Brain fatty acid concentrations differed significantly between the groups for minor fatty acids such as linoleic acid and n-3 docosapentaenoic acid. The profound changes in heart, plasma and liver lipid concentrations suggest a direct effect of chronic exposure to the HIV-1 virus on peripheral lipid (including PUFA) metabolism. |
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Authors:
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Ameer Y Taha; Mireille Basselin; Epolia Ramadan; Hiren R Modi; Stanley I Rapoport; Yewon Cheon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2012-08-29 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 87 ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2012 Oct-Nov |
Date Detail:
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Created Date: 2012-10-09 Completed Date: 2013-02-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 91-101 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. ameer.taha@nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Cholesterol / blood, metabolism Cholesterol Esters / blood, metabolism Fatty Acids, Unsaturated / blood HIV-1 / genetics, physiology* Humans Lipid Metabolism / genetics, physiology* Lipids Liver / metabolism* Male Myocardium / metabolism* Rats Rats, Inbred F344 Rats, Transgenic Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol Esters; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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