| Altered levels of insulin-like growth factor binding protein proteases in preeclampsia and intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 20658698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrauterine growth restriction (IUGR) and preeclampsia (PE) are leading causes of perinatal and maternal morbidity and mortality. Many studies have found association between low levels of insulin-like growth factor binding protein (IGFBP) proteases in the first trimester maternal circulation and the risk of subsequent development of PE and/or IUGR. These results are generally interpreted to reflect decreased production of the proteases by the placenta, leading to reduced proteolysis of IGFBPs and lower free levels of insulin-like growth factor (IGF), resulting in diminished feto-placental development. However, the association between low circulating levels of placental proteins early in pregnancy and the subsequent development of IUGR and/or PE could be due to low exchange in the placenta and not due to reduced production. In contrast, late in pregnancy, the circulating levels of these proteins and their expression in the placenta are often elevated in PE, which may reflect upregulation to compensate for abnormal placental development, that is an adaptive mechanism to increase IGFBP proteolysis, increase local IGF levels and promote feto-placental growth. Further research into the biological mechanisms underlying these associations will aid the identification of high-risk pregnancies and the development of therapeutic targets for diseases for which there are presently no preventative measures. |
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Authors:
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Julian K Christians; Andrée Gruslin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 815-20 Citation Subset: IM |
Copyright Information:
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(c) 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Biological Sciences, Simon Fraser University, Burnaby, BC, Canada. julian_christians@sfu.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fetal Growth Retardation / blood, metabolism* Humans Insulin-Like Growth Factor Binding Proteins / blood Placenta / metabolism Placenta Diseases / blood, metabolism Pre-Eclampsia / blood, metabolism* Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Third Serine Endopeptidases / blood, metabolism* Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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MOP-84542//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Proteins; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/insulin-like growth factor binding proteinase, human |
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