| Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. | |
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MedLine Citation:
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PMID: 19401681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Schizophrenia is characterized by complex and dynamically interacting perturbations in multiple neurochemical systems. In the past, evidence for these alterations has been collected piecemeal, limiting our understanding of the interactions among relevant biological systems. Earlier, both hyper- and hyposerotonemia were variously associated with the longitudinal course of schizophrenia, suggesting a disturbance in the central serotonin (5-hydroxytryptamine (5-HT)) function. Using a targeted electrochemistry-based metabolomics platform, we compared metabolic signatures consisting of 13 plasma tryptophan (Trp) metabolites simultaneously between first-episode neuroleptic-naive patients with schizophrenia (FENNS, n=25) and healthy controls (HC, n=30). We also compared these metabolites between FENNS at baseline (BL) and 4 weeks (4w) after antipsychotic treatment. N-acetylserotonin was increased in FENNS-BL compared with HC (P=0.0077, which remained nearly significant after Bonferroni correction). N-acetylserotonin/Trp and melatonin (Mel)/serotonin ratios were higher, and Mel/N-acetylserotonin ratio was lower in FENNS-BL (all P-values<0.0029), but not after treatment, compared with HC volunteers. All three groups had highly significant correlations between Trp and its metabolites, Mel, kynurenine, 3-hydroxykynurenine and tryptamine. However, in the HC, but in neither of the FENNS groups, serotonin was highly correlated with Trp, Mel, kynurenine or tryptamine, and 5-hydroxyindoleacetic acid (5HIAA) was highly correlated with Trp, Mel, kynurenine or 3-hydroxykynurenine. A significant difference between HC and FENNS-BL was further shown only for the Trp-5HIAA correlation. Thus, some metabolite interactions within the Trp pathway seem to be altered in the FENNS-BL patients. Conversion of serotonin to N-acetylserotonin by serotonin N-acetyltransferase may be upregulated in FENNS patients, possibly related to the observed alteration in Trp-5HIAA correlation. Considering N-acetylserotonin as a potent antioxidant, such increases in N-acetylserotonin might be a compensatory response to increased oxidative stress, implicated in the pathogenesis of schizophrenia. |
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Authors:
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J K Yao; G G Dougherty; R D Reddy; M S Keshavan; D M Montrose; W R Matson; S Rozen; R R Krishnan; J McEvoy; R Kaddurah-Daouk |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-04-28 |
Journal Detail:
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Title: Molecular psychiatry Volume: 15 ISSN: 1476-5578 ISO Abbreviation: Mol. Psychiatry Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-07 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607835 Medline TA: Mol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 938-53 Citation Subset: IM |
Affiliation:
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Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA. jkyao@pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antipsychotic Agents Female Humans Hydroxyindoleacetic Acid / metabolism Kynurenine / analogs & derivatives, metabolism Male Melatonin / metabolism Oxidative Stress / physiology* Schizophrenia / metabolism* Serotonin / analogs & derivatives, metabolism Tryptophan / metabolism* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00056/RR/NCRR NIH HHS; MH45203/MH/NIMH NIH HHS; MH58141/MH/NIMH NIH HHS; MH64118/MH/NIMH NIH HHS; R01 MH058141-05/MH/NIMH NIH HHS; R24 GM078233/GM/NIGMS NIH HHS; UL1 RR024153/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 1210-83-9/N-acetylserotonin; 343-65-7/Kynurenine; 484-78-6/3-hydroxykynurenine; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 73-22-3/Tryptophan; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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