| Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. | |
| | |
MedLine Citation:
|
PMID: 21443585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Rosa JS, Oliver SR, Flores RL, Ngo J, Milne GL, Zaldivar FP, Galassetti PR. Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Obesity (Ob) and type 1 diabetes (T1DM) are associated with increased inflammation and oxidative stress, which are major pathogenetic pathways toward higher cardiovascular risks. Although long-term exercise protects against systemic inflammation and oxidation, acute exercise actually exerts pro-inflammatory and oxidative effects, prompting the necessity for better defining these molecular processes in at-risk patients; in particular, very little is known regarding obese and T1DM children. We therefore examined key inflammatory and oxidative stress variables during exercise in 138 peripubertal children (47 Ob, 12.7 ± 0.4 yr, 22 F, BMI% 97.6 ± 0.2; 49 T1DM, 13.9 ± 0.2 yr, 20 F, body mass index% [BMI] 63.0 ± 3.6; 42 healthy, CL, 13.5 ± 0.5 yr, 24 F, BMI% 57.0 ± 3.6), who performed 10 bouts of 2-min cycling ∼80% VO(2max) , separated by 1-min rest intervals. Blood samples were drawn at baseline and peak exercise. Ob displayed elevated baseline interleukin-6 (IL-6, 2.1 ± 0.2 pg/mL, p < 0.005) vs. CL (1.5 ± 0.3), whereas T1DM displayed the greatest maximum exercise-induced change in IL-6 (1.2 ± 0.3) than in both Ob (0.7 ± 0.1, p < 0.001) and CL (0.6 ± 0.1, p < 0.0167). Myeloperoxidase (MPO) was elevated in T1DM (143 ± 30 ng/mL, p < 0.0167) vs. CL (89 ± 10) and Ob (76 ± 6), whereas increases in exercise only occurred in Ob and CL. Disparate baseline and exercise responses were also observed for 8-hydroxy-2'-deoxyguanosine, glutathione, and F(2) -isoprostane. This data show distinct patterns of dysregulation in baseline and adaptive immunologic and oxidative responses to exercise in Ob and T1DM. A full understanding of these alterations is required so that developing exercise regimens aimed at maximizing health benefits for specific dysmetabolic states can be achieved based on complete scientific characterization rather than empirical implementation. |
| | |
Authors:
|
Jaime S Rosa; Stacy R Oliver; Rebecca L Flores; Jerry Ngo; Ginger L Milne; Frank P Zaldivar; Pietro R Galassetti |
Related Documents
:
|
6885575 - Effects of ph on maximal power output and fatigue during short-term dynamic exercise. 16586325 - Characteristics of inline speedskating--incremental tests and effect of drafting. 16794025 - Mca vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip. 8029245 - Effect of concurrent exercise and physostigmine on lactate and pyruvate in plasma, musc... 20354445 - Effects of exercise training on resting energy expenditure and lean mass during pediatr... 9095475 - Muscle ubiquinone in male effort angina patients. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
|
Title: Pediatric diabetes Volume: - ISSN: 1399-5448 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 John Wiley & Sons A/S. |
Affiliation:
|
Department of Pharmacology, School of Medicine, University of California, Irvine, CA, USA Institute for Clinical Translational Science, Department of Pediatrics, University of California, Irvine, CA, USA Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lower HbA1c after 1 year, in children with type 1 diabetes treated with insulin glargine vs. NPH ins...
Next Document: Effective treatment of hypoglycemia in children with type 1 diabetes: a randomized controlled clinic...