Document Detail

Altered hemodynamics during exercise in older essential hypertensive subjects.
MedLine Citation:
PMID:  3192293     Owner:  NLM     Status:  MEDLINE    
This study was designed to compare the resting and exercise hemodynamics of older adults with moderate hypertension with those of age-matched normotensive controls. Thirty-one hypertensive (20 men, 11 women; mean age, 63.9 +/- 2.8 years) and 28 normotensive subjects (15 men, 13 women; mean age, 62.6 +/- 2.4 years) were studied. There were no differences between the groups in terms of body weight, body composition, and maximal O2 consumption (VO2). At rest, there were no differences in VO2, cardiac output, stroke volume, or heart rate between the two groups, although systolic (158 +/- 13 vs 121 +/- 12 mm Hg) and diastolic blood pressures (94 +/- 7 vs 79 +/- 8 mm Hg) were higher in the hypertensive subjects. The hypertensive subjects' elevated blood pressure at rest was the result of a higher total peripheral resistance. During exercise, the hypertensive subjects had a lower cardiac output and stroke volume, no difference in heart rate and VO2, higher systolic, diastolic, and mean blood pressures, and a higher total peripheral resistance compared with their normotensive peers. The results indicate that older hypertensive persons have an altered cardiovascular response to exercise as compared with age-matched normotensive subjects. The responses also indicate that older essential hypertensive persons do not undergo excessive myocardial demands during exercise of the intensity usually prescribed in rehabilitation programs.
S J Montain; S M Jilka; A A Ehsani; J M Hagberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  12     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-28     Completed Date:  1988-12-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Aging / physiology
Blood Pressure
Cardiac Output
Heart Rate
Hypertension / physiopathology*
Middle Aged
Vascular Resistance
Grant Support
AG-03038/AG/NIA NIH HHS; P01-05562//PHS HHS; RR-00036/RR/NCRR NIH HHS

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